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Synfacts 2011(5): 0536-0536
DOI: 10.1055/s-0030-1259784
DOI: 10.1055/s-0030-1259784
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Rhodium-Catalyzed Coupling of Terminal Alkynes with Carboxylic Acids
A. Lumbroso, P. Koschker, N. R. Vautravers, B. Breit*
Albert-Ludwigs-Universität Freiburg, Germany
Further Information
Publication History
Publication Date:
15 April 2011 (online)
Significance
A new rhodium-catalyzed propargylic C-H activation of readily available terminal alkynes and their coupling with carboxylic acids to furnish branched allylic esters has been developed. This method tolerates a broad range of functional groups on both the alkyne and the carboxylic acid reaction partner.