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Synfacts 2011(3): 0289-0289
DOI: 10.1055/s-0030-1259499
DOI: 10.1055/s-0030-1259499
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Rhodium-Catalyzed Asymmetric Hydrogenation of Phosphonobutenoates
Z.-C. Duan, X.-P. Hu*, C. Zhang, Z. Zheng*
Dalian Institute of Chemical Physics and Graduate School of Chinese Academy of Sciences, Beijing, P. R. of China
Further Information
Publication History
Publication Date:
16 February 2011 (online)
Significance
In this paper, the authors report a protocol that allows the synthesis of highly optically active phosphonates via direct rhodium asymmetric hydrogenation of 3-aryl-4-phosphonobutenoates with a modified P-stereogenic BoPhoz-type ligand. Various substituents on the aromatic ring are well tolerated and the enantioselectivities as well as yields are very high.