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Synfacts 2011(3): 0304-0304
DOI: 10.1055/s-0030-1259481
DOI: 10.1055/s-0030-1259481
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Enantioselective Mannich-Type Three-Component Reaction
X. Xu, Y. Qian, L. Yang, W. Hu*
East China Normal University, Shanghai, P. R. of China
Further Information
Publication History
Publication Date:
16 February 2011 (online)
Significance
In recent years, multicomponent as well as domino reactions have received considerable attention in light of their relevance to atom economy (see Book below). The authors report a multicomponent reaction involving the generation of a rhodium carbenoid and its reaction with aldim-ines under chiral Brønsted acid catalysis. The use of a transition metal as well as an an organocatalyst in situ is significant. This work follows the group’s earlier explorations of domino reactions involving diazo compounds (Angew. Chem. Int. Ed. 2010, 49, 2190).
Book: Multicomponent Reactions, J. Zhu, H. Bienaymé, Eds.; Wiley-VCH: Weinheim, 2005.