A One-Pot Tandem Reaction System Using Resin-Supported Peptide

K. Akagawa; T. Fujiwara; S. Sakamoto; K. Kudo

doi:10.1055/s-0030-1259136

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Synfacts 2011(1): 0107-0107
DOI: 10.1055/s-0030-1259136

Polymer-Supported Synthesis

A One-Pot Tandem Reaction System Using Resin-Supported Peptide

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Maki Minakawa
K. Akagawa, T. Fujiwara, S. Sakamoto, K. Kudo*
The University of Tokyo, Japan

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Publication History

Publication Date:
21 December 2010 (online)

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Significance

An efficient one-pot tandem reaction of the oxidation of primary alcohols and the asymmetric α-oxyamination using a resin-supported peptide and CuCl was described. The tandem reaction of primary alcohols 2a-g with TEMPO, the resin-supported peptide 1, CuCl, and 2,2′-bipyridine followed by reduction with NaBH₄ gave the corresponding oxyaminated products 3a-g.