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Synfacts 2011(1): 0085-0085  
DOI: 10.1055/s-0030-1259117
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Carbonylative Conjugate Addition of Dialkylzinc Reagents

Contributor(s): Paul Knochel, Andreas J. Wagner
D. W. Custar, H. Le, J. P. Morken*
Boston College, Chestnut Hill, USA
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Publication History

Publication Date:
21 December 2010 (online)

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Significance

1,4-Diketones are obtained in good yields from the addition of organozinc reagents to unsaturated carbonyls in the presence of carbon monoxide. Various substituted cyclic and acyclic ketones as well as unsaturated aldehydes are suitable substrates for this reaction.