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Synfacts 2010(12): 1425-1425  
DOI: 10.1055/s-0030-1258930
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Practical Enantioselective One-Pot Syntheses of β-Hydroxy and β-Amino Esters

Contributor(s): Benjamin List, Anna Lee
H. Jiang, B. Gschwend, Ł. Albrecht, K. A. Jørgensen*
Aarhus University, Denmark
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Publication History

Publication Date:
22 November 2010 (online)

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Significance

A practical and efficient one-pot synthesis of β-amino and β-hydroxy esters via epoxidation or aziridination followed by an internal redox reaction is described. Jørgensen and co-workers obtained the desired products in good yields and high enantioselectivities with low catalyst loadings (1-2.5 mol%). The authors also show the synthetic utility of this organocatalysis sequence.