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Synfacts 2010(12): 1375-1375  
DOI: 10.1055/s-0030-1258904
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Solvent-Free Magnesium-Catalyzed Enantioselective Ketone-Ene Reactions

Contributor(s): Hisashi Yamamoto, Jiajing Tan
K. Zheng, Y. Yang, J. Zhao, C. Yin, L. Lin, X. Liu, X. Feng*
Sichuan University, Chengdu, P. R. of China
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Publication History

Publication Date:
22 November 2010 (online)

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Significance

Highly functionalized molecules with a trifluoromethylated quaternary stereocenter can be obtained by asymmetric ketone-ene ­reaction of trifluoropyruvate catalyzed by a new Mg(OTf)2 complex of a N,N′-dioxide ligand. A wide range of trifluoromethyl-substituted products were easily accessed with excellent yields and enantio­selectivities.