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Synfacts 2010(11): 1321-1321
DOI: 10.1055/s-0030-1258832
DOI: 10.1055/s-0030-1258832
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Sequential Suzuki-Miyaura/Heck Reaction Using Pd/SiO2
L. Joucla, G. Cusati, C. Pinel, L. Djakovitch*
Université de Lyon, Villeurbanne, France
Further Information
Publication History
Publication Date:
21 October 2010 (online)
Significance
The authors described the sequential Suzuki-Miyaura/Heck reactions using a silica-supported palladium catalyst (Pd/SiO2) for the preparation of (E)-stilbenes in one pot. Thus, the Suzuki-Miyaura reaction of iodoarenes 1a-g and potassium vinyltrifluoroborate (2) using Pd/SiO2 and the subsequent Heck reaction with the addition of 3-bromoquinoline (4) were carried out in one pot to give the corresponding stilbenes 5a-g in 44-80% yield.