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Synfacts 2010(11): 1260-1260  
DOI: 10.1055/s-0030-1258764
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Oxidative Carbofunctionalization of Indenes

Contributor(s): Mark Lautens, David A. Candito
S. Kirchberg, R. Fröhlich, A. Studer*
Westfälische Wilhelms-Universität, Münster, Germany
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Publication History

Publication Date:
21 October 2010 (online)

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Significance

The authors report on the palladium-catalyzed diastereoselective carbofunctionalization of indenes utilizing TEMPO as a stoichiometric oxidant and trapping agent. The authors previously reported a similar strategy in which a diastereoselective carboaminoxylation of indoles was carried out (Angew. Chem. Int. Ed. 2009, 48, 4235). There are only a few reports on intermole­cular metal-mediated oxidative carbofunctionali­zation.