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Synfacts 2010(10): 1106-1106  
DOI: 10.1055/s-0030-1258623
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Dactylolide

Contributor(s): Steven V. Ley, Catherine F. Carter
S. Y. Yun, E. C. Hansen, I. Volchkov, E. J. Cho, W. Y. Lo, D. Lee*
University of Illinois at Chicago, USA
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

Unnatural (-)-dactylolide displays biological activity against several tumor cell lines, such as L1210 and SK-OV-3. The key step of the synthesis is an ene-yne coupling reaction of G with boronate H followed by allylic transposition to afford coupling partner J.