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Synlett 2010(16): 2474-2476  
DOI: 10.1055/s-0030-1258569
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Nef-Perkow Access to Indolizine Derivatives

Didier Coffinier*, Laurent El Kaim*, Laurence Grimaud*
Laboratoire Chimie et Procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris Cedex 15, France
Fax: +33(1)45525587; e-Mail: didier.coffinier@laposte.net; e-Mail: laurent.elkaim@ensta.fr; e-Mail: laurence.grimaud@ensta.fr;
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Publication History

Received 2 August 2010
Publication Date:
14 September 2010 (online)

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Abstract

We present herein a new access to indolizine derivatives involving 1,3-dipolar cycloaddition of pyridinium ylides with phosphorylated hydroxyketenimines. These ketenimines are easily formed via a Nef-Perkow cascade involving isocyanides as starting material.

Key words

Nef reaction - isocyanide - indolizine - pyridinium ylide - cycloaddition

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