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Synthesis 2010(18): 3163-3173  
DOI: 10.1055/s-0030-1258181
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Facile Access to Biaryls and 2-Acetyl-5-arylbenzofurans via Suzuki Coupling in Water under Thermal and Microwave Conditions

Ahmed F. Darweesha, Mohamed R. Shaabana,b, Ahmad M. Faraga, Peter Metzc, Kamal M. Dawood*a
a Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
Fax: +20(2)35727556; e-Mail: dr_dawood@hotmail.com;
b Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukarramah, Saudi Arabia
c Fachrichtung Chemie und Lebensmittelchemie, Organische Chemie I, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany
Further Information

Publication History

Received 12 March 2010
Publication Date:
16 July 2010 (online)

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Abstract

The phosphine-free Suzuki-Miyaura carbon-carbon cross-coupling reactions of activated and deactivated aryl halides and 2-acetyl-5-bromobenzofuran with various aryl- or heteroarylboronic acids were investigated. A benzothiazole-based palladium(II) complex was used as a precatalyst for the reactions under both thermal and microwave conditions in air using water as a solvent.

Key words

palladium - catalysis - microwave irradiation - Suzuki reactions - benzofuran

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