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Synfacts 2010(8): 0916-0916
DOI: 10.1055/s-0030-1257784
DOI: 10.1055/s-0030-1257784
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Addition of Trialkylaluminium Regents to Extended Michael Acceptors
M. Tissot, D. Müller, S. Belot, A. Alexakis*
Université de Genève, Switzerland
Further Information
Publication History
Publication Date:
22 July 2010 (online)
Significance
The authors report their work on copper-catalyzed addition of organometallic reagents to extended Michael acceptors. Reactions of organometallic nucleophiles with unsaturated acceptors are well established (see Review below). This work adds to the field by utilizing a ligand giving higher enantioselectivity then earlier examples. Furthermore, 1,6- versus 1,4-regioselectivity is discussed.
Review: J. Christoffers, G. Koripelly, A. Rosiak, M. Rössle Synthesis 2007, 1279-1300.