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Exp Clin Endocrinol Diabetes 2010; 118(1): 64-67
DOI: 10.1055/s-0029-1225647
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Increased Ceruloplasmin and Fibrinogen in Type 2 Diabetes Corresponds to Decreased Anti-oxidant Activity in a Preliminary Tertiary South Indian Hospital Study

S. K. Chacko1 , R. Cheluvappa2
  • 1MBBS Program, Father Muller Medical College, Kankanady, Mangalore, Karnataka, India
  • 2Department of Medicine, St. George Clinical School and Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, Sydney, Australia
Further Information

Publication History

received 14.04.2009 first decision 20.05.2009

accepted 12.06.2009

Publication Date:
15 October 2009 (online)

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Abstract

The relationship between type 2 diabetes, antioxidant-enzyme serum ceruloplasmin, pro-inflammatory blood fibrinogen and antioxidant activity (AOA) was investigated in 40 diabetics and 47 non-diabetics hailing from South India as a preliminary study aspiring to be a crucial stepping stone for a large study. Serum AOA was lower (p<0.01) in diabetics (0.68±0.03 mmol/L) than controls (0.92±0.07 mmol/L) and ceruloplasmin more (p<0.001) in diabetics (983.20±52.18 mg/L) than controls (470.79±39.20 mg/L). Plasma fibrinogen was higher (p<0.001) in diabetics (480.23±19.52 mg/dl) than controls (313.94±13.42 mg/dl). Males had more AOA. Fibrinogen increased with age. These significant findings point strongly to augmented oxidative stress and inflammatory states in South Indian diabetics.

Key words

antioxidant activity - oxidative stress - HbA1c - ceruloplasmin - fibrinogen - type 2 diabetes

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Correspondence

Dr. R. CheluvappaMBBS, PhD 

Centre for Infection and Inflammation Research

School of Medical Sciences, Wallace Wurth Building

University of New South Wales, Gate 9 High Street

Sydney, NSW 2052

Australia

Phone: +61/0406/0406 20

Fax: +61/02/9385 13 89

Email: r.cheluvappa@unsw.edu.au

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