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Synfacts 2010(7): 0738-0738  
DOI: 10.1055/s-0029-1220107
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Auripyrones A and B

Contributor(s): Steven V. Ley, Kimberley A. Roper
I. Hayakawa, T. Takemura, E. Fukasawa, Y. Ebihara, N. Sato, T. Nakamura, K. Suenaga, H. Kigoshi*
University of Tsukuba and Keio University, Yokohama, Japan
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Publication History

Publication Date:
22 June 2010 (online)

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Significance

Auripyrones A and B were isolated from a sea hare and exhibit cytotoxicity against HeLaS3 cells with the δ-pyrone functional group thought to be important for activity. Auripyrone A has been previously synthesized using a spiroacetalization approach (Angew. Chem. Int. Ed. 2006, 45, 2560), but the ­absolute configuration of auri­pyrone B was unknown.