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Synfacts 2010(7): 0837-0837  
DOI: 10.1055/s-0029-1220088
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Alkylation of Indoles with a Sulfonated Carbon-Based Solid Acid

Contributor(s): Yasuhiro Uozumi, Tsubasa Muto
J. Ma, S. Ng, Y. Yong, X.-Z. Luo, X. Wang, X.-W. Liu*
Nanyang Technological University, Singapore
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Publication History

Publication Date:
22 June 2010 (online)

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Significance

A sulfonated amorphous carbonbased solid acid catalyzed the alkylation of indoles 1 with α,β-unsaturated carbonyl compounds 2 in water to give the corresponding alkylated indoles 3 in up to 96% yield (15 examples).