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Synfacts 2010(6): 0667-0667  
DOI: 10.1055/s-0029-1219975
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

New Ligands for Rhodium-Catalyzed Asymmetric 1,4-Additions

Contributor(s): Hisashi Yamamoto, Jiajing Tan
F. Lang, D. Li, J. Chen, J. Chen, L. Li, L. Cun, J. Zhu, J. Deng, J. Liao*
Chengdu Institute of Organic Chemistry, Graduate School of Chinese Academy of Science, Beijing and Jiangxi Normal University, Nanchang, P. R. of China
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Publication History

Publication Date:
20 May 2010 (online)

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Significance

A new type of tert-butanesulfinyl­phosphine ligands is successfully synthesized and applied to the rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to cyclic or acyclic unsaturated ketones. Excellent yield and good enantioselectivity are observed under mild conditions. The stereochemical outcome of this reaction is also discussed.