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Synfacts 2010(6): 0670-0670  
DOI: 10.1055/s-0029-1219903
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Ruthenium-Catalyzed Enantioselective Diels-Alder Reaction of β-Keto Esters

Contributor(s): Hisashi Yamamoto, Patrick Brady
C. Schotes, A. Mezzetti*
ETH Zürich, Switzerland
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Publication History

Publication Date:
20 May 2010 (online)

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Significance

This is the first enantioselective method for the synthesis of tetrahydro-1-indan­ones. The product contains an all-carbon quaternary center. The method can be used to synthesize estrone derivatives, which are important for their potential medicinal properties.