Asymmetric Synthesis of Fluorohydrins

Significance

Due to the unique properties of ­fluorinated organic molecules they are prevalent in pharmaceutically active agents. Thus, methods for the asymmetric synthesis of useful chiral ­fluorine-containing building blocks are highly sought after. The authors report a dual-catalyst system consisting of a chiral amine and a chiral (salen)Co complex for the nucleophilic epoxide ring opening with a latent source of fluoride. The protocol delivers useful fluorohydrins in superior yields and enantioselectivities under mild reaction conditions.