Gold-Catalyzed γ-Selective Amination of Allylic
Alcohols

P. Mukherjee; R. A. Widenhoefer

doi:10.1055/s-0029-1219859

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Synfacts 2010(6): 0663-0663
DOI: 10.1055/s-0029-1219859

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Gold-Catalyzed γ-Selective Amination of Allylic Alcohols

Contributor(s): Mark Lautens, Stephen G. Newman
P. Mukherjee, R. A. Widenhoefer*
Duke University, Durham, USA

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Publication History

Publication Date:
20 May 2010 (online)

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Significance

Amination of allylic alcohols is an efficient method for the synthesis of useful allyl amines. While examining intermolecular hydroamination chemistry, the authors discovered a highly γ-selective allylation of amines utilizing a cationic gold(I) catalyst.