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Synthesis 2010(10): 1731-1735  
DOI: 10.1055/s-0029-1219748
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Novel Mono- and Bis(spiro-2-amino-4H-pyrans): Alum-Catalyzed Reaction of 4-Hydroxycoumarin and Malononitrile with Isatins, Quinones, or Ninhydrin

Ali Reza Karimi*, Fahime Sedaghatpour
Department of Chemistry, Arak University, Arak 38156, Iran
Fax: +98(861)4173406; e-Mail: a-karimi@araku.ac.ir;
Further Information

Publication History

Received 8 February 2010
Publication Date:
06 April 2010 (online)

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Abstract

Some new mono- and bis(spiro-2-amino-4H-pyrans) are synthesized by the multicomponent condensation reaction of 4-hydroxycoumarin and malononitrile with isatins, ninhydrin, 9,10-phenanthrenequinone, or acenaphthenequinone. Alum was found to be a suitable and efficient catalyst for this condensation.

Key words

alum [KAl(SO4)2˙12H2O] - spiro-2-amino-4H-pyrans - 4-hydroxycoumarin

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