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Synlett 2010(5): 745-748  
DOI: 10.1055/s-0029-1219361
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

K-10-Catalyzed Highly Diastereoselective Synthesis of Aziridines

Dmitry Borkin, Alena Carlson, Béla Török*
Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd. Boston, MA 02125, USA
Fax: +1(617)2876030; e-Mail: bela.torok@umb.edu;
Further Information

Publication History

Received 24 November 2009
Publication Date:
08 February 2010 (online)

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Abstract

A new solid acid-catalyzed method was developed for the stereoselective preparation of cis-aziridines from imines and ethyl diazoacetate using montmorillonite K-10 as catalyst. The ­reactions proceeded readily at room temperature in short reaction times, providing the products in excellent yields (90%) and exclusive selectivity.

Key words

montmorillonite K-10 - imines - aziridines - ethyl diazo­acetate - heterogeneous catalysis

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