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Synfacts 2010(3): 0344-0344  
DOI: 10.1055/s-0029-1219306
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Titanocene-Catalyzed 1,4-Reduction of α,β-Unsaturated Carbonyl Compounds

Contributor(s): Paul Knochel, Andrei Gavryushin
A. D. Kosal, B. L. Ashfeld*
University of Notre Dame, USA
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Publication History

Publication Date:
18 February 2010 (online)

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Significance

A simple catalytic protocol for the 1,4-reduction of α,β-unsaturated carbonyl compounds using inexpensive zinc dust as a reducing agent is described. A number of functionalized enals, enones, and acrylic esters can be successfully reduced into the corresponding saturated ­analogues in good to excellent yields.