Palladium-Catalyzed Arylation in Polyethylene Glycol under
Air

L. Ackermann; R. Vicente

doi:10.1055/s-0029-1219282

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Synfacts 2010(3): 0362-0362
DOI: 10.1055/s-0029-1219282

Polymer-Supported Synthesis

Palladium-Catalyzed Arylation in Polyethylene Glycol under Air

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Hidetoshi Ohta
L. Ackermann*, R. Vicente
Georg-August-Universität, Göttingen, Germany

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Publication History

Publication Date:
18 February 2010 (online)

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Significance

Palladium-catalyzed arylation of N-substituted 1,2,3-triazoles 1 with aryl bromides 2 was examined in polyethylene glycol (PEG) under air. Thus, the reaction of 1 with 2 was carried out in the presence of Pd(OAc)₂, MesCO₂H, and K₂CO₃ in PEG under atmospheric air to give the corresponding products 3 in 52-85% yield with C-5 regioselectivity.