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Synfacts 2010(3): 0298-0298  
DOI: 10.1055/s-0029-1219268
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Thymidine Nucleotide Sensor

Contributor(s): Timothy M. Swager, Jeewoo Lim
Z. Zeng, L. Spiccia*
Monash University, Victoria, Australia
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Publication History

Publication Date:
18 February 2010 (online)

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Significance

Simple methods of sensing nucleo­tides in aqueous environments may provide useful insights into biological pathways and could lead to novel methods in diagnosis of various diseases. The authors report a sensory molecule composed of a zinc(II)-cyclen core with pendant pyrene groups. When thymidine nucleotide binds this molecule, the two pyrene groups are brought together, leading to a turn-on of pyrene excimer emission (470 nm) with concomitant turn-off of pyrene monomer emission (375 nm).