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Synfacts 2010(3): 0266-0266  
DOI: 10.1055/s-0029-1219253
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Angelichalcone

Contributor(s): Steven V. Ley, Philippa B. Cranwell
J. J. Topczewski, M. P. Callahan, J. D. Neighbors, D. F. Wiemer*
University of Iowa, USA
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Publication History

Publication Date:
18 February 2010 (online)

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Significance

(+)-Angelichalcone was isolated from Angelica keiskei, a herb used in traditional Japanese medicine. This is the first total synthesis of the target. Other related geranylated chalcones, with the same aromatic substitution but various oxidation states along the geranyl chain, have also been isolated.