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Synthesis 2010(7): 1176-1080  
DOI: 10.1055/s-0029-1219228
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Concise Access to Pyrimidine-Annulated Azepine and Azocine Derivatives by Ruthenium-Catalyzed Ring-Closing Metathesis

K. C. Majumdar*, Shovan Mondal, Debankan Ghosh
Department of Chemistry, University of Kalyani, Kalyani 741235, WB, India
e-Mail: kcm_ku@yahoo.co.in;
Further Information

Publication History

Received 24 November 2009
Publication Date:
20 January 2010 (online)

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Abstract

Synthetic approaches to five- and six-membered-ring systems are commonly undertaken through cyclization and cycloaddition reactions, but the formation of seven- and eight-membered-ring systems are not as abundant. An efficient and high-yielding method for the synthesis of seven- and eight-membered-ring nitrogen-containing heterocycles by ring-closing metathesis is reported.

Keywords

uracil - azepine - azocine - ring-closing metathesis

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