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Synthesis 2010(7): 1181-1187  
DOI: 10.1055/s-0029-1219224
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Total Synthesis of Ailanthoidol, Egonol, and Related Analogues

Xin-Fang Duan*, Gang Shen, Zhan-Bin Zhang
Department of Chemistry, Beijing Normal University, Beijing, 100875, P. R. of China
Fax: +86(10)58802075; e-Mail: xinfangduan@vip.163.com;
Further Information

Publication History

Received 26 November 2009
Publication Date:
12 January 2010 (online)

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Abstract

Efficient and general synthetic protocols were developed for the total synthesis of ailanthoidol, egonol, and some related analogues. The key transformations describe here involve a two-step construction of the benzofuran and a Sonogashira coupling, and proved to be convenient and effective, starting from readily available reagents.

Key words

benzofurans - cross-coupling - McMurry reaction - ­Sonogashira coupling - natural products

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