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Synthesis 2010(15): 2631-2635
DOI: 10.1055/s-0029-1218827
DOI: 10.1055/s-0029-1218827
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Direct Oxidative Conversion of Alcohols, Amines, Aldehydes, and Benzyl Halides into the Corresponding Nitriles with Trichloroisocyanuric Acid in Aqueous Ammonia
Further Information
Received
18 February 2010
Publication Date:
18 June 2010 (online)
Publication History
Publication Date:
18 June 2010 (online)
Abstract
A new and efficient procedure for the one-pot conversion of various alcohols, aldehydes and primary amines into the corresponding nitriles in excellent yields was easily achieved by trichloroisocyanuric acid (TCCA) as an oxidant and reagent in aqueous ammonia. Also, various benzylic halides were smoothly and directly converted into the corresponding aromatic nitriles in high yields under the same conditions.
Key words
trichloroisocyanuric acid - nitriles - alcohols - amines - aldehydes - alkyl halides
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