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Synthesis 2010(10): 1687-1691  
DOI: 10.1055/s-0029-1218765
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

An Efficient, One-Pot, Regioselective Synthesis of 1,4-Diaryl-1H-1,2,3-triazoles Using Click Chemistry

Dalip Kumar*, Vaddula Buchi Reddy
Chemistry Group, Birla Institute of Technology and Science, Pilani, Rajasthan-333 031, India
Fax: +91(1596)244183; e-Mail: dalipk@bits-pilani.ac.in;
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Publication History

Received 4 January 2010
Publication Date:
29 April 2010 (online)

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Abstract

An efficient, one-pot, regioselective synthesis of 1,4-diaryl-1H-1,2,3-triazoles is described via the copper(I)-catalyzed reaction of diaryliodonium salts, sodium azide and terminal alkynes. The generality of this protocol is demonstrated by the synthesis of a series of 1,4-diaryl-1H-1,2,3-triazoles in good to high yields. The catalyst and reaction solvent are reused without any appreciable reduction in product yield.

Key words

1,4-diaryl-1H-1,2,3-triazoles - click chemistry - diaryl­iodonium salts - aryl azides - cycloaddition

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