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Synthesis 2010(7): 1075-1077  
DOI: 10.1055/s-0029-1218656
SHORTPAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Novel Synthetic Approaches to (Trifluoromethyl)triazoles

Dmytriy A. Sibgatulina,b, Andrii V. Bezdudnya,b, Pavel K. Mykhailiuk*a,c, Nataliia M. Voievodaa,c, Ivan S. Kondratova,d, Dmitry M. Volochnyuka,b, Andrey A. Tolmacheva,c
a Enamine Ltd., Alexandra Matrosova Street 23, 01103 Kiev, Ukraine
Fax: +380(44)2351273; e-Mail: Pashamk@gmx.de;
b Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska Street 5, 02660 Kiev-94, Ukraine
c Department of Chemistry, Kiev National Taras Shevchenko University, Volodymyrska Street 64, 01033 Kiev, Ukraine
d Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Murmanska Street 1, 02660 Kiev-94, Ukraine
Further Information

Publication History

Received 26 November 2009
Publication Date:
29 January 2010 (online)

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Abstract

New synthetic procedures for the trifluoromethyl-substituted triazoles, 3-(trifluoromethyl)-4H-1,2,4-triazole and 4-(trifluoromethyl)-1H-1,2,3-triazole, have been elaborated. The target compounds were prepared from commercially available trifluoro­acethydrazide (one step) and methyl propiolate (three steps), respectively.

Key words

fluorine - triazoles - trifluoromethyl group

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