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Synthesis 2010(5): 803-806  
DOI: 10.1055/s-0029-1218584
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

An Efficient, One-Pot, Multicomponent Synthesis of β-Acetamido Carbonyl Compounds Using Cyanuric Chloride in an Aqueous Medium [¹]

Biswanath Das*, Malampati Srilatha, Boyapati Veeranjaneyulu, Bethapudi Rama Rao
Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500 007, India
Fax: +91(40)27193198; e-Mail: biswanathdas@yahoo.com;
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Publication History

Received 19 October 2009
Publication Date:
07 December 2009 (online)

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Abstract

A one-pot, three-component reaction between an aromatic aldehyde, an enolizable ketone or a β-keto ester, and a nitrile in the presence of acetyl chloride is accomplished efficiently using cyanuric chloride in an aqueous medium to give the corresponding β-acetamido ketone or ester in high yield.

Key words

β-acetamido ketone - multicomponent reaction - cyanuric chloride - aqueous medium

1

Part 198 in the series ‘Studies on novel synthetic methodologies’.

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1

Part 198 in the series ‘Studies on novel synthetic methodologies’.