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Synlett 2009(16): 2601-2604  
DOI: 10.1055/s-0029-1217980
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of 6-Substituted Imidazo[2,1-b][1,3]thiazoles and 2-Substituted Imidazo[2,1-b][1,3]benzothiazoles via Pd/Cu-Mediated Sonogashira Coupling

Taghi A. Kamalia, Davood Habibib, Mahmoud Nasrollahzadeh*b
a Laboratory of Organic Chemistry, Moshashimi Company, Kardikola Industrial Region, Babol 47571-54879, Iran
b Department of Organic Chemistry, Faculty of Chemistry, Bu Ali Sina University, Hamedan 6517838683, Iran
Fax: +98(811)8257407; e-Mail: mahmoudnasr81@gmail.com;
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Publication History

Received 26 June 2009
Publication Date:
14 September 2009 (online)

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Abstract

The reaction of iodobenzenes with 2-amino-3-(2-pro­pynyl)-1,3-thiazolium bromide and 2-imino-3-(2-propynyl)-1,3-benzothiazole, catalyzed by Pd/Cu, leads to the formation of 6-substituted imidazo[2,1-b][1,3]thiazoles and 2-substituted imidazo[2,1-b][1,3]benzothiazoles, respectively.

Key words

Sonogashira coupling - aryl iodide - imidazothiazole - Pd-catalyzed - sodium lauryl sulfate

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