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Exp Clin Endocrinol Diabetes 1995; 103(6): 367-372
DOI: 10.1055/s-0029-1211380
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The effects of streptozocin-induced diabetes on renal plasma flow

A. Baykal-Erkiliç, M. Erkiliç, T. Özben
  • Biochemistry Department, Medical Faculty of Akdeniz University, Antalya, Turkey
  • Nuclear Medicine Department, Medical Faculty of Akdeniz University, Antalya, Turkey
  • Biochemistry Department, Medical Faculty of Akdeniz University, Antalya, Turkey
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Publication History

Publication Date:
15 July 2009 (online)

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Summary

To evaluate the significance of collagen levels, honenzymatic glycation, and effective renal plasma flow in diabetes, we studied 52 Streptozocin induced-diabetic fats. After 10 weeks of diabetes, rats were injected i.v 0.5 μ/g 99mTechnetium Mercaptoacetyl triglycine and effective renal plasma flow was calculated from the renonrams obtained. The collagen content and hydroxy-Bethyl furfural levels of kidney and tail tissue as well as renal plasma flow increased significantly in diabetic rats (p<0.05). The increase in renal plasma flow indicates that hyperperfusion may play a role in diabetic nephropathy mechanism. The correlation between renal plasma flow and glycation was not as high as the correlations between blood glucose concentrations and hydroxymethyl furfural and collagen levels, suggesting that factors other than glycation are important in increasing the renal plasma flow.

Key words

Hydroxyproline - MAG3 - animal

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