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Exp Clin Endocrinol Diabetes 1995; 103(5): 339-342
DOI: 10.1055/s-0029-1211375
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Age modulates effects of thyroid dysfunction on sex hormone binding globulin (SHBG) levels

P. Lecomte, N. Lecureuil** , M. Lecureuil** , C. Osorio Salazar, C. Valat*
  • Médecine B — Endocrinologie, UFR Pharmacie, Tours, France
  • * Médecine Nucléaire, CHRU Bretonneau, UFR Pharmacie, Tours, France
  • ** Laboratoire de Biophysique et Biomathématique, UFR Pharmacie, Tours, France
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Publication History

Publication Date:
15 July 2009 (online)

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Summary

Symptoms of thyroid dysfunction are difficult to detect in elderly people and TSH is sometimes unreliable. We therefore tested the value of SHBG as la marker of thyroid hormone action on the liver to determine the thyroid status of elderly people. Aging euthyroid men and women have a significant increase in SHBG (p > 0.0001). In aging women the decrease in SHBG with hypothyroidism and increase with hyperthyroidism are highly significant (p < 0.0001 and p < 0.0005 respectively). No significant variation in SHBG was observed in men with thyroid dysfunction. SHBG can help to determine the thyroid status of aging women.

Key words

Aging - SHBG - thyroid dysfunction - hypothyroidism - hyperthyroidism

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