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Exp Clin Endocrinol Diabetes 1994; 102(3): 193-194
DOI: 10.1055/s-0029-1211282
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Gestagens in peripheral, uterine, ovarian and fetal blood in cows near term

T. Janowski
  • Department of Obstetrics, Faculty of Veterinary Medicine, Academy of Agriculture and Technology, Olsztyn, Poland
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Publication History

Publication Date:
15 July 2009 (online)

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Summary

The aim of this study was to determine if bovine placenta is capable of producing the gestagen metabolites in vivo. The concentrations of 5ß-pregnane-3a-20a-diol, 17a,20a-dihydroxyprogesterone and progesterone were measured by HPLC-RIA in samples obtained after surgical preparation from peripheral, uterine, fetal and ovarian blood of seven cows near term. Measurement of arterio-venous differences in maternal uterine and umbilical circulation confirmed the placental origin of 5ß-pregnance-3a,20a-diol and 17a,20a-dihydroxyprogesterone, but not progesterone itself. 5ß-pregnane-3a, 20a-diol was preferentially secreted into the fetal compartment. The present experiment, according to earlier in-vitro studies, confirms that the preterm bovine placenta is qualified for in-vivo utilization and secretion of gestagen metabolites.

Key words

gestagens - placenta - cow - parturition

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