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Exp Clin Endocrinol Diabetes 1992; 100(6): 95-98
DOI: 10.1055/s-0029-1211185
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Adrenergic Mechanism in Hyperketonemia in Thyrotoxic and Starved Rats

T. Ikeda, H. Ochi, I. Ohtani, K. Fujiyama, T. Hoshino, Y. Tanaka, T. Takeuchi, H. Mashiba
  • The first Department of Internal Medicine, Tottori University School of Medicine, Yonago/Japan
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Publication History

1991

Publication Date:
16 July 2009 (online)

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Summary

To evaluate the possible role of the adrenergic mechanism in hyperketonemia in hyperthyroidism and starvation, the plasma concentrations of FFA, acetoacetate (AcAc), and ß-hydroxybutyrate (BOHB) were measured in thyrotoxic and starved rats for 96 hours. Thyrotoxemia was induced in rats by a daily subcutaneous thyroxine (100 µg/kg/day) injection carried out for 7 days. Some of the thyrotoxic and starved rats were administered subcutaneous phentolamine (2 mg/kg, twice daily) or propranolol (0.1 mg/kg, twice daily). Plasma levels of FFA, Ac Ac, and BOHB were significantly increased in thyrotoxic and starved rats compared with the control rats. Phentolamine and propranolol administration did not alter plasma levels of FFA, Ac Ac, and BOHB in thyrotoxic rats. In starved rats, propanolol did not alter plasma levels of FFA, Ac Ac, and BOHB, however, phentolamine did increase plasma levels of FFA, Ac Ac, and BOHB. These results indicate that the adrenergic mechanism may not contribute to the hyperketonemia in thyrotoxic rats, but may have a slight inhibitory effect on ketogenesis in starvation probably due to α-antilipolytic action.

Key words

Hyperketonemia - Starvation - Hyperthyroidism - Phentolamine - Propranolol

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