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Exp Clin Endocrinol Diabetes 1992; 99(2): 110-112
DOI: 10.1055/s-0029-1211148
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Influence of the Electrical Stimulation of the Hypothalamus on Adrenocortical Steroidogenesis in Hypophysectomized Rats

H. Saito, T. Sato, H. Kaba, M. Tadokoro, N. Edashige1 , K. Seto, F. Kimura2 , M. Kawakami2
  • First Department of Physiology (Chairman: Prof. K. Seto), Kochi Medical School, Nankoku
  • 1Department of Medical Technology (Chairman: Prof. Y. Agatsuma), Kochi Gakuen College, Kochi
  • 2Department of Physiology (Chairman: Prof. F. Kimura), Yokohama City University School of Medicine, Yokohama/Japan
Further Information

Publication History

1991

Publication Date:
15 July 2009 (online)

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Summary

The electrical stimulation of the ventromedial hypothalamus (VMH), lateral hypothalamic area (LHA), periventricular arcuate nucleus (ARC), and posterior hypothalamus (PHY), on 14C transfer rates from 14C-1-acetate into adrenocortical steriods in adrenal slices of hypophysectomized rats were investigated. The 14C transfer rates into corticosterone and cortisol were increased by the stimulation of the VMH, ARC, and PHY, but decreased by the stimulation of the LHA. From these results, it might be suggested that these hypothalamic structures were involved in the regulation of adrenocortical steroidogenesis without participation of the pituitary.

Key words

Hypothalamus - Adrenocortical steroids - Hypophysectomized rats

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