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Exp Clin Endocrinol Diabetes 1989; 94(4/05): 223-225
DOI: 10.1055/s-0029-1210902
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Splenopentin-Induced Reconstitution of the Immune Response after Total Body Irradiation: Optimization of Treatment Regime *)

R. Eckert, R. Schmidt, H.-D. Volk, W. Diezel, N. Sönnichsen, R. von Baehr
  • Institute of Medical Immunology and Department of Dermatology, Medical School (Charité), Humboldt University, Berlin, GDR
*) Dedicated to Professor Dr. G. Dörner on the occasion of his 60th birthday.
Further Information

Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

In former investigations our group obtained an immuno-reconstituting effect in mice treated by immunosuppression after a continuous treatment with splenopentin (SP5). The goal of the present study was to test whether a small number of injections right after immunosuppression possibly produces the same result in the sense of an initial effect. Although a short-term therapy induced an increase of antibody formation which was measurable after 4 weeks, the study clearly showed that only a continuous treatment by SP5 led to an optimum, i.e. complete reconstitution of antibody formation.

Key words

Splenopentin - Immunosuppression - Antibody formation - Reconstitution

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