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Exp Clin Endocrinol Diabetes 1989; 94(4/05): 203-210
DOI: 10.1055/s-0029-1210898
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Studies on the Biotransformation of the Progestagen Dienogest in the Rabbit *)

G. Hobe, Renate Schön, K. Wehrberger, W. Schade, Petra Ritter, H. G. Hillesheim
  • Academy of Sciences of the GDR, Research Centre of Biosciences and Medicine, Central Institute of Microbiology and Experimental Therapy, Jena (Director: Prof. Dr. F. Bergter), Division of Steroid Research (Head: Prof. Dr. C. Hörhold), Jena, GDR
*) To Prof. Dr. Dr. G. Dörner on occasion of his 60th birthday.
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Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

Following administration of 14α, 15α-3H-Dienogest (STS 557, 17α-cyanomethyl-17β-hydroxy-4,9-estradien-3-one) to female rabbits, extracts from urine, bile and plasma were separated by means of HPLC. Urinary and biliary metabolites are characterized by patterns of high complexity. From the mass spectra and UV absorption data of the urinary Dienogest metabolites a variety of biotransformation reactions has been derived like : hydroxylation in different positions of the Dienogest molecule, among these the 11-position; reduction of the 3-oxo group to 3-hydroxy ; introduction of 2 and 4 hydrogen atoms; aromatization of ring A; transformation of 17α-CH2CN to CH2OH, and formation of compounds with a 5(10), 9(ll)-diene structure. Some of these reactions occur simultaneously resulting in a very complicated metabolite spectrum. Possibly the multiple effects of Dienogest established in animals are partially caused by metabolites.

Key words

Synthetic progestagen - 3H-Dienogest - Metabolite pattern - Biotransforma-tion - Female rabbits

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