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Exp Clin Endocrinol Diabetes 1989; 94(4/05): 187-193
DOI: 10.1055/s-0029-1210896
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Pathogenetic Role of Adipose Tissue Lipase Deficit for Development of Hypertriglyceridaemia*)

U. Julius, W. Leonardt, D. Noack, J. Schulze, Nina G. Nikulcheva, W. Jaross, M. Hanefeld
  • Department of Metabolic Diseases and Endocrinology, Lipid Research Unit (Head: Prof. Dr. sc. med. M. Hanefeld), Clinic of Internal Medicine (Director: Prof. Dr. sc. med. H.-U. Schentke) and Institute of Clinical Chemistry and Laboratory Diagnostics (Head: Prof. Dr. sc. med. W. Jaroß) of the Medical Academy “Carl Gustav Cams”, Dresden, GDR, Department of Biochemistry (Head: Academician Prof. A. N. Klimov) of the Institute for Experimental Medicine (Head: Prof. Dr. N. P. Bechtereva) of the Academy of Medical Sciences of the USSR, Leningrad, USSR
*) In honour of Prof. Dr. sc. med. G. Dörner on the occasion of his 60th birthday.
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Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

In 87 patients (74 males, 13 females; age 43 ± 9.2 years) covering a wide range of triglyceride (TG) concentrations (8.8 to 80.7 mmol/1) the turnover of total serum TG has been measured using the technique of labelling endogenously synthesized TG with 3H-glycerol. In parallel, lipoprotein lipase activity in adipose tissue and the adipose-tissue lipase activity in post-heparin plasma have been assessed following an oral 50 g glucose load. Despite the well-recognized function of this enzyme for intravascular lipolysis no direct relationship between lipase activities and fractional catabolic rates (FCR), reflecting TG removal processes, was found. On the other hand, relative enzyme activities (per TG moles) are positively correlated with the FCR. However, a detailed analysis of this relationship revealed that only in HTG patients whose FCR are below 0.210 h−1 a rate-limiting influence of a relative lipase deficit can be shown. In these patients, a statistically significant elevation of concentrations of free fatty acids is supposed to contribute to the impairment of the TG removal.

Key Words

Lipoprotein lipase - Adipose tissue - Triglyceride turnover - Hypertriglyceridaemia

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