Neuropediatrics 2008; 39(6): 351-353
DOI: 10.1055/s-0029-1202289
Short Communication

© Georg Thieme Verlag KG Stuttgart · New York

Normal Neurological Outcome after Congenital Thyrotoxicosis: Prognostic Value of Observation of General Movements

M. Gaboli 1 , S. Aguilera 1 , C. Azcona 2 , V. Alzina 3 , J. Narbona 1
  • 1Paediatric Neurology Unit, Department of Paediatrics, University of Navarra Medical School, Pamplona, Spain
  • 2Paediatric Endocrinology Unit, University of Navarra Medical School, Pamplona, Spain
  • 3Neonatal Unit, Department of Paediatrics, University of Navarra Medical School, Pamplona, Spain
Further Information

Publication History

received 13.10.2008

accepted 29.12.2008

Publication Date:
30 June 2009 (online)

Abstract

We followed up a patient born preterm with congenital thyrotoxicosis by observing her general movements (GMs) in accordance with Prechtl's method. Initially a chaotic pattern was observed. Along with the normalization of thyroid hormones, the GM pattern changed to a poor repertoire at four weeks of life, full-blown writhing movements at six weeks and fidgety movements at the age of four months. This is the first report of chaotic GMs in a neonate reflecting transient neurological dysfunction related to congenital thyrotoxicosis, with subsequent normal neurological and cognitive outcome.

References

  • 1 Amiel-Tison C, Grenier A. Evaluation neurologique du nouveau-né et du nourrisson. Paris: Masson 1980
  • 2 Bos AF, Loon AJ van, Hadders-Algra M. et al . Spontaneous motility in preterm, small-for-gestational age infants II. Qualitative aspects.  Early Hum Dev. 1997;  50 131-147
  • 3 Bruggink JLM, Einspieler C, Butcher PR. et al . The quality of the early motor repertoire in preterm infants predicts minor neurological dysfunction at school age.  J Pediatr. 2008;  153 32-39
  • 4 Daneman D, Howard NJ. Neonatal thyrotoxicosis: intellectual impairment and craniosynostosis in later years.  J Pediatr. 1980;  97 257-259
  • 5 Einspieler C, Prechtl HFR, Bos AF. et al .PrecthlŽs method on the qualitative assessment of general movements in preterm, term and young infants. In: Hart HM, ed. Clinics in Developmental Medicine No. 167. London: Mac Keith Press 2004
  • 6 Ferrari F, Prechtl HFR, Cioni G. et al . Posture, spontaneous movements, and behavioural state organisation in infants affected by brain malformations.  Early Hum Dev. 1997;  50 87-113
  • 7 Mitsuda N, Tamaki H, Amino N. et al . Risk factors for developmental disorders in infants born to women with GravesŽ disease.  Obstet Gynecol. 1992;  80 359-364
  • 8 Mussa GC, Mussa F, Bretto R. et al . Influence of thyroid in nervous system growth.  Minerva Pediatr. 2001;  53 325-353
  • 9 Saint-Anne-Dargaissies S. Le développement neurologique du nouveau-né à terme et prématuré. Paris: Masson 1974
  • 10 Zimmerman D. Fetal and neonatal hyperthyroidism.  Thyroid. 1999;  9 727-733

Correspondence

Dr. J. Narbona

Paediatric Neurology Unit

Department of Paediatrics

University of Navarra Medical School

Avenida Pio XII s/n

31080 Pamplona

Spain

Phone: +34/94/829 62 36

Fax: +34/94/829 65 00

Email: jnarbona@unav.es

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