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Fortschr Neurol Psychiatr 2010; 78(2): 90-100
DOI: 10.1055/s-0028-1109979
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Psychose und Sucht bei Jugendlichen und Jungerwachsenen
Teil 2: Verlauf und Behandlung

Dual Diagnosis Psychosis and Substance Use Disorders in Adolescents – Part 2K. Meister1 , L. Rietschel1 , M. Burlon1 , E. Gouzoulis-Mayfrank2 , T. Bock1 , M. Lambert1
  • 1Psychosen-Ersterkennungs- und Behandlungsprojekt (PEB), Klinik für Psychiatrie und Psychotherapie, Zentrum für Psychosoziale Medizin, Universitätskrankenhaus Hamburg-Eppendorf (Direktor: Prof. Dr. D. Naber)
  • 2LVR-Klinik Köln und Klinik für Psychiatrie und Psychotherapie, Universitätsklinik Köln (Direktor: Prof. Dr. J. Klosterkötter)
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Publication History

Publication Date:
09 February 2010 (online)

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Zusammenfassung

Trotz hoher Prävalenz der Doppeldiagnose (DD) Psychose und Sucht bei ersterkrankten Jugendlichen und Jungerwachsenen und hoher klinischer Relevanz, bedingt durch den ungünstigen Krankheitsverlauf bei persistierendem Drogenkonsum, existieren nur wenige randomisierte kontrollierte Therapiestudien. Nach therapeutischen Empfehlungen sollte bei dieser Gruppe die psychiatrische Therapie und Suchttherapie integriert werden. Dieser Beitrag skizziert integrierte Versorgungsmodelle und störungsspezifische Kurzzeittherapien aus klinischer und evidenzbasierter Perspektive mit Fokus auf die für DD-Patienten adaptierte Motivationsbehandlung, deren Effektivität bei Suchtstörungen alleine belegt ist. Ziel dieses Beitrags ist es, psychosoziale Behandlungen aufzuzeigen, die den Substanzkonsum bei Jugendlichen und Jungerwachsenen mit Psychose effizient reduzieren könnten. Fünf randomisiert kontrollierte Studien werden besprochen. Diese Überblicksarbeit findet keine Überlegenheit einer speziellen psychosozialen Intervention. Entweder konnten gefundene Effekte nicht repliziert werden oder es konnte kein klarer Vorteil gegenüber Vergleichsbedingungen für substanzspezifische oder andere psychiatrische Zielkriterien bestätigt werden.

Abstract

Despite the high prevalence of comorbid substance use disorders (SUD) in young schizophrenic patients and the association of persisting SUD and poor outcome, there are only few randomized controlled psychological treatment studies in this special dual diagnosis group available. According to therapeutic recommendations, efficient treatment models need to integrate traditional psychiatric therapy and therapy of addiction offered in one setting. Short-term interventions have adapted Motivational interviewing (MI) for dual diagnosis, which has been shown to be effective among other substance abuse disorders. However a recent Cochrane review showed that insufficient evidence exists to show that any psychosocial treatment method for dual diagnosis is superior to others. The aim of this review was to assess the current evidence for the efficacy of psychosocial interventions for reducing substance in young patients with psychosis. Five randomized-controlled studies were identified. This review did not find any specific psychosocial intervention that had been replicated and consistently showed clear advantages over comparison condition for substance-related and other psychiatric outcomes.

Schlüsselwörter

Doppeldiagnose - Krankheitsverlauf - integrierte Versorgung - störungsspezifische Psychotherapien - Evidenzbasierung

Key words

dual diagnosis - psychosis - substance use disorder - clinical course - evidence-based psychosocial treatments

Literatur

  • 1 Lambert M, Conus P, Lubman D I. et al . The impact of substance use disorders on clinical outcome in 643 patients with first-episode psychosis.  Acta Psychiatrica Scandinavica. 2005;  112 141-148
    Google Scholar
  • 2 Harrison I, Joyce E M, Mutsatsa S H. et al . Naturalistic follow-up of co-morbid substance use in schizophrenia: the West London first-episode study.  Psychological Medicine. 2008;  38 79-88
    Google Scholar
  • 3 Bartels S J, Drake R, Wallach W A. Long-term course of substance use disorders among patients with severe mental illness.  Psychiatric Services. 1995;  46 248-251
    Google Scholar
  • 4 Drake R E, McHugo G J, Xie H. et al . Ten-year recovery outcomes for clients with co-occurring schizophrenia and substance use disorders.  Schizophrenia Bulletin. 2006;  32 464-473
    Google Scholar
  • 5 Xie H, McHugo G J, Helmstetter B S. et al . Three-year recovery outcomes for long-term patients with co-occurring schizophrenic and substance use disorders.  Schizophrenia Research. 2005;  75 337-348
    Google Scholar
  • 6 Drake R E, Wallach M A, McGovern M P. Future directions in preventing relapse to substance abuse among clients with severe mental illnesses.  Psychiatric Services. 2005;  56 1297-1302
    Google Scholar
  • 7 Hides L, Dawe S, Kavanagh D J. et al . Psychotic symptom and cannabis relapse in recent-onset psychosis.  British Journal of Psychiatry. 2006;  189 137-143
    Google Scholar
  • 8 Wade D, Harrigan S, Edwards J. et al . Course of substance misuse and daily tobacco use in first-episode psychosis.  Schizophrenia Research. 2006;  81 145-150
    Google Scholar
  • 9 Addington J, Addington D. Patterns, predictors and impact of substance use in early psychosis: a longitudinal study.  Acta Psychiatrica Scandinavica. 2007;  115 304-309
    Google Scholar
  • 10 Caspari D. Cannabis and schizophrenia: results of a follow-up study.  European Archives of Psychiatry and Clinical Neuroscience. 1999;  249 45-49
    Google Scholar
  • 11 Farrelly S, Harris M G, Henry L G. et al . Prevalence and correlates of comorbidity 8 years after a first psychotic episode.  Acta Psychiatrica Scandinavica. 2007;  116 62-70
    Google Scholar
  • 12 Westermeyer J. Comorbid schizophrenia and substance abuse: a review of epidemiology and course.  American Journal on Addictions. 2006;  15 345 s-355
    Google Scholar
  • 13 Westermeyer J, Schneekloth T. Course of substance abuse in patients with and without schizophrenia.  American Journal on Addictions. 1999;  8 54-63
    Google Scholar
  • 14 Dixon L. Dual diagnosis of substance abuse in schizophrenia: prevalence and impact on outcomes.  Schizophrenia Research. 1999;  35 93-100
    Google Scholar
  • 15 Linszen D H, Dingemans P M, Lenior M E. Cannabis use and the course of recent onset schizophrenic disorders.  Archives of General Psychiatry. 1994;  51 273-279
    Google Scholar
  • 16 Linszen D H, Dingemans P M, Nugter M A. Patient attributes and expressed emotion as risk factors for psychotic relapse.  Schizophrenia Bulletin. 1997;  23 119-130
    Google Scholar
  • 17 Haywood T W, Kravitz H M, Grossman L S. et al . Predicting the „revolving door” phenomenon among patients with schizophrenic, schizoaffective, and affective disorders.  American Journal of Psychiatry. 1995;  152 856-861
    Google Scholar
  • 18 Wade D, Harrigan S, Whelan G. et al . The impact of substance use disorders on clinical outcome in first-episode psychosis.  Schizophrenia Research. 2004;  67 172
    Google Scholar
  • 19 Margolese H C, Negrete J C, Tempier R. et al . A 12-month prospective follow-up study of patients with schizophrenia-spectrum disorders and substance abuse: Changes in psychiatric symptoms and substance use.  Schizophrenia Research. 2006;  83 65-75
    Google Scholar
  • 20 Talamo A, Centorrino F, Tondo L. et al . Comorbid substance-use in schizophrenia: relation to positive and negative symptoms.  Schizophrenia Research. 2006;  86 251-255
    Google Scholar
  • 21 Wade D, Harrigan S, McGorry P D. et al . Impact of severity of substance use disorder on symptomatic and functional outcome in young individuals with first-episode psychosis.  Journal of Clinical Psychiatry. 2007;  68 767-774
    Google Scholar
  • 22 Margolese H C, Malchy L, Negrete J C. et al . Drug and alcohol use among patients with schizophrenia and related psychoses: levels and consequences.  Schizophrenia Research. 2004;  67 157-166
    Google Scholar
  • 23 Janssen B, Gaebel W, Haerter M. et al . Evaluation of factors influencing medication compliance in inpatient treatment of psychotic disorders.  Psychopharmacology. 2006;  187 229-236
    Google Scholar
  • 24 Hunt G E, Bergen J, Bashir M. Medication compliance and comorbid substance abuse in schizophrenia: impact on community survival 4 years after a relapse.  Schizophrenia Research. 2002;  54 253-264
    Google Scholar
  • 25 Soyka M. Substance misuse, psychiatric disorder and violent and disturbed behaviour.  British Journal of Psychiatry. 2000;  176 345-350
    Google Scholar
  • 26 Regier D A, Farmer M E, Rae D S. et al . Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study.  Journal of the American Medical Association. 1990;  264 2511-2518
    Google Scholar
  • 27 Goodman L A, Rosenberg S D, Mueser K T. et al . Physical and sexual assault history in women with serious mental illness: prevalence, correlates, treatment, and future research directions.  Schizophrenia Bulletin. 1997;  23 685-696
    Google Scholar
  • 28 Cohen L J, Test M A, Brown R J. Suicide and schizophrenia: data from a prospective community treatment study.  American Journal of Psychiatry. 1990;  147 602-607
    Google Scholar
  • 29 Gut-Fayand A, Dervaux A, Olie J P. et al . Substance abuse and suicidality in schizophrenia: a common risk factor linked to impulsivity.  Psychiatry Research. 2001;  102 65-72
    Google Scholar
  • 30 Buhler B, Hambrecht M, Loffler W. et al . Precipitation and determination of the onset and course of schizophrenia by substance abuse – a retrospective and prospective study of 232 population-based first illness episodes.  Schizophrenia Research. 2002;  54 243-251
    Google Scholar
  • 31 Mueser K T, Yarnold P R, Rosenberg S D. Substance use disorder in hospitalized severely mentally ill psychiatric patients: prevalence, correlates, and subgroups.  Schizophrenia Bulletin. 2000;  26 179-192
    Google Scholar
  • 32 Brunette M F, Mueser K T, Drake R E. A review of research on residential programs for people with severe mental illness and co-occuring substance use disorders.  Drug and Alcohol Review. 2004;  23 471-481
    Google Scholar
  • 33 Bartels S J, Teague G B, Drake R E. Substance abuse in schizophrenia: service utilization and costs.  Journal of Nervous and Mental Disease. 1993;  181 227-232
    Google Scholar
  • 34 Dickey B, Azeni H. Persons with dual diagnosis of substance abuse and major mental illness: their excess costs of psychiatric care.  American Journal of Public Health. 1996;  86 973-977
    Google Scholar
  • 35 Dixon L, Haas G H, Weiden P J. et al . Drug abuse in schizophrenic patients: clinical correlates and reasons for use.  American Journal of Psychiatry. 1991;  148 224-230
    Google Scholar
  • 36 Arndt S, Tyrrell G, Flaum M. et al . Comorbidity of substance abuse and schizophrenia: the role of premorbid adjustment.  Psychological Medicine. 1992;  22 379-388
    Google Scholar
  • 37 Sevy S, Robinson D G, Holloway S. Correlates of substance misuse in patients with first-episode schizophrenia and schizoaffective disorder.  Acta Psychiatrica Scandinavica. 2001;  104 367-374
    Google Scholar
  • 38 Larsen T K, Melle I, Auestad B. et al . Substance abuse in first-episode non-affective psychosis.  Schizophrenia Research. 2006;  88 55-62
    Google Scholar
  • 39 Penk W E, Flannery R B, Irvin E. et al . Characteristics of substance-abusing persons with schizophrenia: the paradox of the dually diagnosed.  Journal of Addictive Diseases. 2000;  19 23-30
    Google Scholar
  • 40 Tsuang M T, Simpson J C, Zronfonl Z. Subtypes of drug abuse with psychosis. Demographic characteristics, clinical features, and family history.  Archives of General Psychiatry. 1982;  38 141-147
    Google Scholar
  • 41 Potvin S, Sephery A A, Stip E. A meta-analysis of negative symptoms in dual diagnosis schizophrenia.  Psychological Medicine. 2006;  36 431-440
    Google Scholar
  • 42 Potvin S, Joyal C C, Pelletier J. et al . Contradictory cognitive capacities among substance-abusing patients with schizophrenia.  Schizophrenia Research. 2008;  100 242-251
    Google Scholar
  • 43 Schnell T, Koethe D, Daumann J. et al . The role of cannabis in cognitive functioning of patients with schizophrenia.  Psychopharmacology. 2009;  205 45-52
    Google Scholar
  • 44 Joyal C C, Hallé P, Lapierre D. et al . Drug abuse and/ or dependence and better neuropsychological performance in patients with schizophrenia.  Schizophrenia Research. 2003;  63 297-299
    Google Scholar
  • 45 Phillips P, Johnson S. How does drug and alcohol misuse develop among people with psychotic illness? A literature review.  Social Psychiatry and Psychiatric Epidemiology. 2001;  36 269-276
    Google Scholar
  • 46 Gouzoulis-Mayfrank E. Komorbidität Psychose und Sucht: Grundlagen und Praxis:. Steinkopff Verlag 2007
    Google Scholar
  • 47 Drake R E, Mueser K T, Brunette M F. et al . A review of treatments for people with severe mental illnesses and co-occurring substance use disorders.  Psychiatric Rehabilitation Journal. 2004;  27 360-374
    Google Scholar
  • 48 Drake R E, O’Neal E L, Wallach M. A systematic review of psychosocial research on psychosocial interventions for people with co-occurring severe mental and substance use disorders.  Journal of Substance Abuse Treatment. 2008;  34 123-138
    Google Scholar
  • 49 Ziedonis D M, Smelson D, Rosenthal R N. et al . Improving the care of individuals with schizophrenia and substance use disorders: consensus recommendations.  Journal of Psychiatric Practice. 2005;  11 315-339
    Google Scholar
  • 50 Mueser K T, Drake D, Sigmon S. et al . Psychosocial interventions for adults with severe mental illnesses and co-occurring substance use disorders: a review of specific interventions.  Journal of Dual Diagnosis. 2005;  1 57-82
    Google Scholar
  • 51 Ridgely M S, Goldman H H, Willenbring M. Barriers to the care of persons with dual diagnoses: organisational and financing issues.  Schizophrenia Bulletin. 1990;  16 123-132
    Google Scholar
  • 52 Osher F C, Drake R E. Reversing a history of unmet needs: approaches to care for persons with co-occurring addictive and mental disorders.  American Journal of Orthopsychiatry. 1996;  66 4-11
    Google Scholar
  • 53 Horn D H, Bux D A. A pilot test of motivational interviewing groups for dually diagnosed inpatients.  Journal of Substance Abuse Treatment. 2001;  20 191-195
    Google Scholar
  • 54 Ridgely M S. Creating integrated programs for severely mentally ill persons with substance disorders.  New Directions for Mental Health Services. 1991;  50 29-41
    Google Scholar
  • 55 Epstein van J, Barker P, Vorburger M. et al .Serious mental illness and its co-occurrence with substance use. Rockville; Substance abuse and mental health services administration, office of applied studies 2004
    Google Scholar
  • 56 Brunette M F, Mueser K T. Psychosocial interventions for the long-term management of patients with severe mental illness and co-occuring substance use disorders.  Journal of Clinical Psychiatry. 2006;  67 10-17
    Google Scholar
  • 57 Cleary M, Hunt G E, Matheson S. et al . Psychosocial treatment programmes for people with both severe mental illness and substance misuse.  Cochrane Database of Systematic Reviews. 2008;  CD001088
    Google Scholar
  • 58 Osher F C, Kofoed L L. Treatment of patients with psychiatric and psychoactive substance use disorders.  Hospital and Community Psychiatry. 1989;  40 1025-1030
    Google Scholar
  • 59 McHugo G J, Drake R E, Burton H L. et al . A scale for assessing the stage of substance abuse treatment in persons with severe mental illness.  Journal of Nervous and Mental Disease. 1995;  183 762-767
    Google Scholar
  • 60 Prochaska J O, DiClemente C C, Norcross J. In search of how people change.  American Psychologist. 1992;  47 1101-1114
    Google Scholar
  • 61 DiClemente C C, Nidecker M, Bellack A S. Motivation and the stages of change among individuals with severe mental illness and substance abuse disorders.  Journal of Substance Abuse Treatment. 2008;  34 25-35
    Google Scholar
  • 62 Dumaine M L. Meta-analysis of interventions with co-occurring disorders of severe mental illness and substance abuse: implications for social work practice.  Research on Social Work Practice. 2003;  13 142-165
    Google Scholar
  • 63 Donald M, Dower J, Kavanagh D J. Integrated versus non-integrated management and care for clients with co-occurring mental health and substance use disorders: a qualitative systematic review of randomised controlled trials.  Social Science and Medicine. 2005;  60 1371-1383
    Google Scholar
  • 64 Carey K B, Purnine D M, Maisto S A. et al . Treating substance abuse in the context of severe and persistent mental illness: Clinicians’ perspectives.  Journal of Substance Abuse Treatment. 2000;  19 189-198
    Google Scholar
  • 65 Laker C J. How reliable is the current evidence looking at the efficacy of harm reduction and motivational interviewing interventions in the treatment of patients with a dual diagnosis?.  Journal of Psychiatric and Mental Health Nursing. 2007;  14 720-726
    Google Scholar
  • 66 Tsuang J, Fong T W, Lesser I L. Psychosocial treatment of patients with schizophrenia and substance abuse disorders.  Addictive Disorders & their Treatment. 2006;  5 53-66
    Google Scholar
  • 67 Drake R E, Mercer-McFadden C, Mueser K T. et al . Review of integrated mental health and substance abuse treatment for patients with dual disorders.  Schizophrenia Bulletin. 1998;  24 589-608
    Google Scholar
  • 68 Gouzoulis-Mayfrank E. Doppeldiagnose Psychose und Sucht – Grundlagen und Therapie.  Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie. 2008;  36 245-253
    Google Scholar
  • 69 Tiet Q Q, Mausbach B. Treatments for patients with dual diagnosis: a review.  Alcoholism: Clinical and Experimental Research. 2007;  31 513-536
    Google Scholar
  • 70 Cleary M, Hunt G E, Matheson S. et al . Psychosocial treatments for people with co-occurring severe mental illness and substance misuse: systematic review.  Journal of Advanced Nursing. 2009;  65 238-258
    Google Scholar
  • 71 Ley A, Jeffery D P, McLaren S. et al . Psychosocial treatment programs for people with both severe mental illness and substance misuse.  The Cochrane Library. 2000;  3 1-37
    Google Scholar
  • 72 McHugo G J, Drake R E, Teague G B. et al . Fidelity to assertive community treatment and client outcomes in the New Hampshire dual disorders study.  Psychiatric Services. 1999;  50 818-824
    Google Scholar
  • 73 Essock S M, Mueser K T, Drake R E. et al . Comparison of ACT and standard case management for delivering integrated treatment for co-occurring disorders.  Psychiatric Services. 2006;  57 185-196
    Google Scholar
  • 74 Tarrier N. Cognitive behaviour therapy for schizophrenia – a review of development, evidence and implementation.  Psychotherapy and Psychosomatics. 2005;  74 136-144
    Google Scholar
  • 75 Jones C, Cormac I, Silveira da Mota Neto J I. et al . Cognitive behaviour therapy for schizophrenia.  Cochrane Database of Systematic Reviews. 2004;  CD000524
    Google Scholar
  • 76 Pekkala E, Merinder L. Psychoeducation for schizophrenia.  Cochrane Database of Systematic Reviews. 2006; 
    Google Scholar
  • 77 Copeland J, Swift W, Roffman R. et al . A randomized controlled trial of brief cognitive – behavioral interventions for cannabis use disorder.  Journal of Substance Abuse Treatment. 2001;  21 55-64
    Google Scholar
  • 78 Bellack A S, DiClemente C C. Treating substance abuse among patients with schizophrenia.  Psychiatric Services. 1999;  50 75-80
    Google Scholar
  • 79 Bellack A S, Bennett M E, Gearon J S. et al . A randomized clinical trial of a new behavioral treatment for drug abuse in people with severe and persistent mental illness.  Archives of General Psychiatry. 2006;  63 426-432
    Google Scholar
  • 80 D’Amelio R, Behrendt B, Wobrock T. Psychoedukation Schizophrenie und Sucht. Manual zur Leitung von Patienten- und Angehörigengruppen. München; Elsevier/Urban & Fischer 2007
    Google Scholar
  • 81 Burlon M, Huber C. Suchtstörungen im Kindes- und Jugendalter: Das Handbuch: Grundlagen und Praxis. Thomasius R, Schulte-Markwort M, Küstner U, et al Stuttgart; Schattauer 2009: 82-87
    Google Scholar
  • 82 Ziedonis D M, Trudeau K. Motivation to quit using substances among individual with schizophrenia: implications for a motivation-based treatment model.  Schizophrenia Bulletin. 1997;  23 229-238
    Google Scholar
  • 83 Miller W R, Rollnick S. Motivational interviewing: preparing people for change. New York; Guilford Press 2002 2nd ed
    Google Scholar
  • 84 Burke B, Arkowitz H, Menchola M. The efficacy of motivational interviewing: a meta-analysis of controlled clinical trials.  Journal of Consulting and Clinical Psychology. 2003;  71 843-861
    Google Scholar
  • 85 Hettema J, Steele J, Miller W R. Motivational interviewing.  Annual Review of Clinical Psychology. 2005;  1 91-111
    Google Scholar
  • 86 Chanut F, Brown T G, Dongier M. Motivational interviewing and clinical psychiatry.  Canadian Journal of Psychiatry. 2005;  50 715-721
    Google Scholar
  • 87 Rogers C R. Client-centered therapy: its current practice, implications, and theory. Boston (MA); Houghton Mifflin 1951
    Google Scholar
  • 88 Festinger L A. A theory of cognitive dissonance. Stanford; Standford University Press 1957
    Google Scholar
  • 89 Carey K B, Leontieva L, Dimmock J. et al . Adapting motivational interventions for comorbid schizophrenia and alcohol use disorders.  Clinical Psychology: Science and Practice. 2007;  14 39-57
    Google Scholar
  • 90 Carey K B, Purnine D M, Maisto S A. et al . Enhancing readiness-to-change substance abuse in persons with schizophrenia. A four-session motivation-based intervention.  Behaviour Modification. 2001;  25 331-384
    Google Scholar
  • 91 Martino S, Carroll K, Kostas D. et al . Dual diagnosis motivational interviewing: A modification of motivational interviewing for substance-abusing patients with psychotic disorders.  Journal of Substance Abuse Treatment. 2002;  23 297-308
    Google Scholar
  • 92 Martino S. Contemplating the Use of Motivational Interviewing With Patients Who Have Schizophrenia and Substance Use Disorders.  Clinical Psychology: Science and Practice. 2007;  14 58-63
    Google Scholar
  • 93 Bechdolf A, Pohlmann B, Reck C. et al . Motivationsbehandlung bei Patienten mit der Doppeldiagnose Psychose und Sucht: Eine Übersicht.  Fortschr Neurol Psychiatr. 2005;  73 728-735
    Google Scholar
  • 94 McHugo G J, Drake R E, Brunette M F. et al . Methodological issues in research on interventions for co-occurring disorders.  Schizophrenia Bulletin. 2006;  32 655-665
    Google Scholar
  • 95 Hulse G K, Tait R J. Six-month outcomes associated with a brief alcohol intervention for adult in-patients with psychiatric disorders.  Drug and Alcohol Review. 2002;  21 105-112
    Google Scholar
  • 96 Martino S, Carroll K M, Nich C. et al . A randomized controlled pilot study of motivational interviewing for patients with psychotic and drug use disorders.  Addiction. 2006;  101 1479-1492
    Google Scholar
  • 97 Martino S, Carroll K M, O’Malley S S. et al . Motivational interviewing with psychiatrically ill substance abusing patients.  American Journal on Addictions. 2000;  9 88-91
    Google Scholar
  • 98 Santa Ana E J, Wulfert E, Nietert P J. Efficacy of group motivational interviewing (GMI) for psychiatric inpatients with chemical dependence.  Journal of Consulting and Clinical Psychology. 2007;  75 816-822
    Google Scholar
  • 99 James W, Koh G, Spencer C. et al .Managing mental health & drug use. Perth, Western Australia; Uniprint 2002
    Google Scholar
  • 100 Gouzoulis-Mayfrank E. Komorbidität von Sucht und anderen psychischen Störungen – Grundlagen und evidenzbasierte Therapie.  Fortschr Neurol Psychiatr. 2008;  76 263-271
    Google Scholar
  • 101 Warren J I, Stein J A, Grella C E. Role of social support and self-efficacy in treatment outcomes among clients with co-occurring disorders.  Drug and Alcohol Dependence. 2007;  89 267-274
    Google Scholar
  • 102 Moher D, Pham B, Jones A. et al . Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?.  Lancet. 1998;  352 609-613
    Google Scholar
  • 103 Swanson A J, Pantalon M V, Cohen K R. Motivational interviewing and treatment adherence among psychiatric and dually diagnosed patients.  Journal of Nervous and Mental Disease. 1999;  187 630-635
    Google Scholar
  • 104 Baker A, Lewin T J, Reichler H. et al . Evaluation of a motivational interview for substance use within psychiatric in-patient services.  Addiction. 2002;  97 1329-1337
    Google Scholar
  • 105 Schmitz J M, Averill P, Sayre S. et al . Cognitive-behavioral treatment of bipolar disorder and substance abuse: a preliminary randomized study.  Addictive Disorders & their Treatment. 2002;  1 17-24
    Google Scholar
  • 106 Weiss R D, Griffin M L, Kolodziej M E. et al . A randomized trial of integrated group therapy versus group drug counseling for bipolar disorder and substance dependence.  American Journal of Psychiatry. 2007;  164 100-107
    Google Scholar
  • 107 Graeber D A, Moyers T B, Griffith G. et al . A pilot study comparing motivational interviewing and an educational intervention in patients with schizophrenia and alcohol use disorders.  Community Mental Health Journal. 2003;  39 189-202
    Google Scholar
  • 108 Bradley A C, Baker A, Lewin T J. Group intervention for coexisting psychosis and substance use disorders in rural Australia: outcomes over 3 years.  Australian and New Zealand Journal of Psychiatry. 2007;  41 501-508
    Google Scholar
  • 109 James W, Preston N J, Koh G. et al . A group intervention which assists patients with dual diagnosis reduce their drug use: a randomised controlled trial.  Psychological Medicine. 2004;  34 983-990
    Google Scholar
  • 110 Kemp R, Harris A, Vurel E. et al . Stop using stuff: trial of a drug and alcohol intervention for young people with comorbid mental illness and drug and alcohol problems.  Australasian Psychiatry. 2007;  15 490-493
    Google Scholar
  • 111 Naeem F, Kingdon D, Turkington D. Cognitive behaviour therapy for schizophrenia in patients with mild to moderate substance misuse problems.  Cognitive Behaviour Therapy. 2005;  34 207-215
    Google Scholar
  • 112 Hjorthøj C, Fohlmann A, Larsen A. et al . Design paper: the CapOpus trial: A randomized, parallel-group, observer-blinded clinical trial of specialized addiction treatment versus treatment as usual for young patients with cannabis abuse and psychosis.  Trials. 2008;  9 42
    Google Scholar
  • 113 Jadad A R, Moore R A, Carrol D. et al . Assessing the quality of reports of randomized clinical trials: is blinding necessary?.  Controlled Clinical Trials. 1996;  17 1-12
    Google Scholar
  • 114 Boutron I, Moher D, Altman D G. et al . Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration.  Annals of internal medicine. 2008;  148 295-309
    Google Scholar
  • 115 Barrowclough C, Haddock G, Tarrier N. et al . Randomized controlled trial of motivational interviewing, cognitive behavior therapy, and family intervention for patients with comorbid schizophrenia and substance use disorders.  American Journal of Psychiatry. 2001;  158 1706-1713
    Google Scholar
  • 116 Baker A, Bucci S, Lewin T J. et al . Cognitive–behavioural therapy for substance use disorders in people with psychotic disorders: Randomised controlled trial.  British Journal of Psychiatry. 2006;  188 439-448
    Google Scholar
  • 117 Baker A, Lee N K, Claire M. et al . Brief cognitive behavioural interventions for regular amphetamine users: a step in the right direction.  Addiction. 2005;  100 367-378
    Google Scholar
  • 118 Bland J M, Kerry S M. Trials randomised in clusters.  British Medical Journal. 1997;  315 600
    Google Scholar
  • 119 Edwards J, Elkins K, Hinton M. et al . Randomized controlled trial of a cannabis-focused intervention for young people with first-episode psychosis.  Acta Psychiatrica Scandinavica. 2006;  114 109-117
    Google Scholar
  • 120 Kavanagh D J, Young R, White A. et al . A brief motivational intervention for substance misuse in recent-onset psychosis.  Drug and Alcohol Review. 2004;  23 151-155
    Google Scholar
  • 121 Haddock G, Barrowclough C, Tarrier N. et al . Cognitive–behavioural therapy and motivational intervention for schizophrenia and substance misuse.  British Journal of Psychiatry. 2003;  183 418-426
    Google Scholar
  • 122 Altman D G, Schulz K F, Moher D. et al . The revised CONSORT statement for reporting randomized trials: explanation and elaboration.  Annals of Internal Medicine. 2001;  134 663-694
    Google Scholar
  • 123 Moher D, Schulz K F, Altman D. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials.  Journal of the American Medical Association. 2001;  285 1987-1991
    Google Scholar
  • 124 Campbell M K, Elbourne D R, Altman D G. CONSORT statement: extension to cluster randomised trials.  British Medical Journal. 2004;  328 702-708
    Google Scholar
  • 125 Cuffel B J. Prevalence estimates of substance abuse in schizophrenia and their correlates.  Journal of Nervous and Mental Disease. 1992;  180 589-592
    Google Scholar
  • 126 Xie H, McHugo G M, Fox M B. Substance abuse relapse in a ten-year prospective follow-up of clients with co-occurring severe mental and substance use disorders.  Psychiatric Services. 2005;  56 1282-1287
    Google Scholar
  • 127 Rollins A L, O’Neill S J, Davis K E. Substance abuse relapse and factors associated with relapse in an inner-city sample of patients with dual diagnoses.  Psychiatric Services. 2005;  56 1274-1281
    Google Scholar
  • 128 Bradizza C M, Stasiewicz P R. Qualitative analysis of high-risk drug and alcohol use situations among severely mentally ill substance abusers.  Addictive Behaviors. 2003;  28 157-169
    Google Scholar
  • 129 Salyers M, Becker D R, Drake R E. A ten-year follow-up of supported employment.  Psychiatric Services. 2004;  55 302-308
    Google Scholar
  • 130 Bradizza C M, Stasiewicz P R, Carey K B. High-risk alcohol and drug use situations among seriously mentally ill patients: a preliminary investigation.  Addictive Behaviors. 1998;  23 555-560
    Google Scholar
  • 131 Alverson H, Alverson M, Drake R E. Social patterns of substance use among people with dual diagnoses.  Mental Health Services Research. 2001;  3 3-14
    Google Scholar
  • 132 Bartels S J, Drake R E. Residential treatment for dual diagnosis.  Journal of Nervous and Mental Disease. 1996;  184 379-381
    Google Scholar
  • 133 Sorbara F, Liraud F, Assens F. et al . Substance use and the course of early psychosis: a 2-year follow-up of first-admitted subjects.  European Psychiatry. 2003;  18 133-136
    Google Scholar
  • 134 Coldham E L, Addingtin J, Addington D. Medication adherence of individuals with a first episode of psychosis.  Acta Psychiatrica Scandinavica. 2002;  106 286-290
    Google Scholar
  • 135 Kamali M, Kelly L, Gervin M. et al . Psychopharmacology: insight and comorbid substance misuse and medication compliance among patients with schizophrenia.  Psychiatric Services. 2001;  52 161-166
    Google Scholar
  • 136 Soyka M, Albus M, Kathmann N. Prevalence of alcohol and drug abuse in schizophrenic inpatients.  European Archives of Psychiatry and Clinical Neuroscience. 1993;  242 362-372
    Google Scholar
  • 137 Verdoux H, Liraud P, Gonzales B. et al . Suicidality and substance misuse in first-admitted subjects with psychotic disorder.  Acta Psychiatrica Scandinavica. 1999;  100 389-395
    Google Scholar
  • 138 Lukoff D, Nuechterlein K H, Ventura J. Manual for expanded Brief Psychiatric Rating Scale (BPRS).  Schizophrenia Bulletin. 1986;  12 594-602
    Google Scholar
  • 139 Beck A T, Steer R A, Brown G K. Beck Depression Inventory: Second Edition Manual. Orlando, FL; Harcourt Brace and Company 1996
    Google Scholar
  • 140 Kay S R, Fiszbein A, Opler L A. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.  Schizophrenia Bulletin. 1987;  13 261-276
    Google Scholar
  • 141 Andreasen N C. Negative symptoms in schizophrenia.  Archives of General Psychiatry. 1982;  39 784-788
    Google Scholar
  • 142 Birchwood M, Smith J, Cochrane R. et al . The Social Functioning Scale: the development and validation of a scale of social adjustment for use in family intervention programmes with schizophrenic patients.  British Journal of Psychiatry. 1990;  157 853-859
    Google Scholar
  • 143 Goldman H H, Skodal A E, Lave T R. Revising axis V for DSM-IV: a review of measures of social functioning.  American Journal of Psychiatry. 1992;  149 1148-1156
    Google Scholar
  • 144 McLellan A T, Kushner H, Metzger D. et al . The fifth edition of the Addiction Severity Index.  Journal of Substance Abuse Treatment. 1992;  9 199-213
    Google Scholar
  • 145 Darke S, Hall W, Wodak A. Development and validation of a multi-dimensional instrument for assessing outcome of treatment among opiate users: the Opiate Treatment Index.  British Journal of Addiction. 1992;  87 733-742
    Google Scholar
  • 146 Mueser K T, Drake R E, Clark R E. et al .Evaluating substance abuse in persons with severe mental illness. Cambridge; Human Services Research Institute 1995
    Google Scholar
  • 147 Raistrick D, Bradshaw J, Tober G. et al . Development of the Leeds Dependence Questionnaire (LDQ): a questionnaire to measure alcohol and opiate dependence in the context of a treatment evaluation package.  Addiction. 1994;  89 563-572
    Google Scholar
  • 148 Wing J K, Babor T, Brugha T. SCAN. Schedules for clinical assessment in neuropsychiatry.  Archives of General Psychiatry. 1990;  47 (6) 589-593
    Google Scholar
  • 149 Saunders J B, Aasland O G, Babor T F. et al . Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on early detection of persons with harmful alcohol consumption-II.  Addiction. 1993;  88 791-804
    Google Scholar
  • 150 Gossop M, Darke S, Griffiths P. The Severity of Dependence Scale (SDS): psychometric properties of the SDS in English and Australian samples of heroin, cocaine and amphetamine users.  Addiction. 1995;  90 607-614
    Google Scholar
  • 151 Rollnick S, Heather N, Gold R. et al . Development of a short „readiness to change” questionnaire for use in brief, opportunistic interventions among excessive drinkers.  British Journal of Addiction. 1992;  87 743-754
    Google Scholar
  • 152 McConnaughy E A, Prochaska J O, Velicer F. Stages of change in psychotherapy: measurement and sample profiles.  Psychotherapy. 1983;  20 368-375
    Google Scholar

PD Dr. Martin Lambert

Psychosen-Ersterkennungs- und Behandlungsprojekt (PEB)
Klinik für Psychiatrie und Psychotherapie, Zentrum für Psychosoziale Medizin
Universitätsklinikum Hamburg-Eppendorf

Martinistr. 52

20246 Hamburg

Email: lambert@uke.de

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