Demethoxycurcumin and its Semisynthetic Analogues as Antitubercular Agents

Abstract

Demethoxycurcumin, isolated from the rhizomes of Curcuma longa, was found to possess antitubercular activity against Mycobacterium tuberculosis H₃₇Rv strain at 200 μg/mL. Derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (MIC) value of 7.8 μg/mL.

Abbreviations

H₃₇Rv:Mycobacterium tuberculosis H₃₇Rv strain

MIC:minimum inhibitory concentration

Key words

Curcuma longa - Zingiberaceae - Mycobacterium tuberculosis - demethoxycurcumin - phenolic derivatives - antitubercular activity

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