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Planta Med 2008; 74(14): 1716-1719
DOI: 10.1055/s-0028-1088318
Letter
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Constituents of Rhodiola rosea Showing Inhibitory Effect on Lipase Activity in Mouse Plasma and Alimentary Canal

Kyoko Kobayashi1 , Keiko Yamada1 , Toshihiro Murata1 , Tatsuya Hasegawa2 , Fumihide Takano2 , Kazutaka Koga3 , Shinji Fushiya3 , Javzan Batkhuu4 , Fumihiko Yoshizaki1
  • 1Department of Pharmacognosy, Tohoku Pharmaceutical University, Sendai, Miyagi, Japan
  • 2Department of Pharmacognosy and Chemistry of Natural Products, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa, Japan
  • 3Department of Kampo Pharmaceutical Sciences, Nihon Pharmaceutical University, Ina-machi, Saitama, Japan
  • 4Department of Biochemistry and Bioorganic Chemistry, Faculty of Biology, National University of Mongolia, Ulaanbaatar, Mongolia
Further Information

Publication History

Received: June 23, 2008 Revised: July 26, 2008

Accepted: July 31, 2008

Publication Date:
03 November 2008 (online)

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Abstract

As a methanol extract of the rhizome of Rhodiola rosea inhibits the activity of lipase in isolated mouse plasma in vitro and in the mouse gastrointestinal tube in vivo, the active components in this plant were investigated. After fractionation and separation processes, rhodionin and rhodiosin were isolated as active ingredients. Their IC50 values were 0.093 mM and 0.133 mM in vitro, respectively. Both compounds significantly suppressed the elevation of the postprandial blood triglyceride level, e. g., by 45.6 % (150 mg/kg, 60 min after oral administration) and 57.6 % (200 mg/kg, 180 min after oral administration), respectively. Consequently, we anticipate the application of this plant and its constituents to the treatment of lifestyle-related diseases such as hyperlipidemia and exogeneous obesity and to health foods.

Key words

Rhodiola rosea - Crassulaceae - lipase - mouse plasma - blood triglyceride - rhodionin - rhodiosin

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Prof. Dr. Fumihiko Yoshizaki

Department of Pharmacognosy

Tohoku Pharmaceutical University

4–1 Komatsushima 4-chome

Aoba-ku

Sendai

Miyagi 981–8558

Japan

Phone: +81-22-727 0221

Fax: +81-22-727 0220

Email: yosizaki@tohoku-pharm.ac.jp

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