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Synthesis 2009(11): 1797-1800  
DOI: 10.1055/s-0028-1088078
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Facile and Practical One-Pot Synthesis of β-Oxo Thioamides from β-Oxo Amides and Isothiocyanates

Peng Huanga, Dexuan Xiangb, Yang Zhoua, Yongjiu Liang*a, Tianhai Naa, Dewen Dong*a,b
a Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. of China
Fax: +86(431)85098966; e-Mail: dwdong@ciac.jl.cn;
b Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. of China
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Publication History

Received 24 December 2008
Publication Date:
27 April 2009 (online)

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Abstract

A facile and practical one-pot synthesis of β-oxo thio­amides from β-oxo amides has been developed. By treatment with isothiocyanates in ethanol in the presence of potassium carbonate, a series of β-oxo amides was converted, under reflux, in high yields into the corresponding β-oxo thioamides.

Key words

thioamides - 3-oxo amides - isothiocyanates - ethanol - potassium carbonate

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