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Synfacts 2009(2): 0196-0196
DOI: 10.1055/s-0028-1087653
DOI: 10.1055/s-0028-1087653
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Addition of LiCH2I to Imines: An Efficient Synthesis of Aziridines
H. Rodríguez-Solla, C. Simal
Universidad de Oviedo, Spain
Further Information
Publication History
Publication Date:
22 January 2009 (online)
Significance
A simple and rapid experimental protocol for the synthesis of aziridines from aldimines is reported for the first time. The use of a chiral aldimine yielded the corresponding chiral aziridine with very high diastereoselectivity and excellent enantiomeric excess.