Mehr als nur ein Mückenstich: der Umgang mit dem West-Nil-Virus im Feld

Dieser Scoping-Review des West-Nil-Virus bei Equiden hebt Schlüsselkonzepte hervor und hofft, Einblicke in Übertragungswege, rechtliche Vorschriften und Fallstricke bei klinischen Symptomen zu geben. Es werden detaillierte Informationen zu Diagnostik und Präventionsmaßnahmen – insbesondere Impfung und Immunprotektion – gegeben, um gut vorbereitet in die kommende Mückensaison zu starten.

Publication History

Article published online:
19 September 2025

• Literatur

• 1 de Heus P. Surveillance of West Nile Virus in Equids in Eastern Austria [Dissertation]. Wien, Österreich: Veterinärmedizinische Universität Wien; 2020
• 2 European Centre for Disease Prevention and Control (ECDC). Surveillance of West Nile virus infections in humans and animals in Europe, monthly report (December 2024). https://www.ecdc.europa.eu/en/infectious-disease-topics/west-nile-virus-infection/surveillance-and-disease-data/monthly-updates%23:~:text=In%25202024%252C%2520and%2520as%2520of,2024%2520and%252025%2520October%25202024%2520 Stand: 24.03.2025
• 3 Weissenböck H, Kolodziejek J, Url A. et al. Emergence of Usutu virus, an African mosquito-borne flavivirus of the Japanese encephalitis virus group, central Europe. Emerg Infect Dis 2002; 8: 652-656
• 4 Süss J. Tick-borne encephalitis 2010: epidemiology, risk areas, and virus strains in Europe and Asia – an overview. Ticks Tick Borne Dis 2011; 2: 2-15
• 5 Camp JV, Nowotny N. The knowns and unknowns of West Nile virus in Europe: what did we learn from the 2018 outbreak?. Expert Rev Anti Infect Ther 2020; 18: 145-154
• 6 Kutasi O, Bakonyi T, Lecollinet S. et al. Equine encephalomyelitis outbreak caused by a genetic lineage 2 West Nile virus in Hungary. J Vet Intern Med 2011; 25: 586-591
• 7 Bouzalas IG, Diakakis N, Chaintoutis SC. et al. Emergence of Equine West Nile Encephalitis in Central Macedonia, Greece, 2010. Transbound Emerg Dis 2016; 63: e219-e227
• 8 Danis K, Papa A, Theocharopoulos G. et al. Outbreak of West Nile virus infection in Greece, 2010. Emerg Infect Dis 2011; 17: 1868-1872
• 9 Barzon L, Pacenti M, Franchin E. et al. The complex epidemiological scenario of West Nile virus in Italy. Int J Environ Res Public Health 2013; 10: 4669-4689
• 10 Brault AC, Huang CY-H, Langevin SA. et al. A single positively selected West Nile viral mutation confers increased virogenesis in American crows. Nat Genet 2007; 39: 1162-1166;
• 11 Cannon AB, Luff JA, Brault AC. et al. Acute encephalitis, polyarthritis and myocarditis associated with West Nile virus infection in a dog. J Vet Intern Med 2006; 20: 1219-1223
• 12 Csank T, Drzewnioková P, Korytár L. et al. A Serosurvey of Flavivirus Infection in Horses and Birds in Slovakia. Vector Borne Zoonotic Dis 2018; 18: 206-213
• 13 Hubálek Z, Tomešek M, Kosina M. et al. West Nile virus outbreak in captive and wild raptors, Czech Republic, 2018. Zoonoses Public Health 2019; 66: 978-981
• 14 Klenk K, Snow J, Morgan K. et al. Alligators as West Nile virus amplifiers. Emerg Infect Dis 2004; 10: 2150-2155
• 15 Padgett KA, Reisen WK, Kahl-Purcell N. et al. West Nile virus infection in tree squirrels (Rodentia: Sciuridae) in California, 2004–2005. Am J Trop Med Hyg 2007; 76: 810-813
• 16 Pradier S, Lecollinet S, Leblond A. West Nile virus epidemiology and factors triggering change in its distribution in Europe. Rev Sci Tech 2012; 31: 829-844
• 17 Rimoldi G, Mete A, Adaska JM. et al. West Nile Virus Infection in Sheep. Vet Pathol 2017; 54: 155-158
• 18 Stiasny K, Aberle SW, Heinzl FX. Retrospective identification of human cases of West Nile virus infection in Austria (2009 to 2010) by serological differentiation from Usutu and other flavivirus infections. Euro Surveill 2013; 18: 20614
• 19 Chancey C, Grinev A, Volkova E. et al. The global ecology and epidemiology of West Nile virus. Biomed Res Int 2015; 2015: 376230
• 20 Rudolf I, Šebesta O, Straková P. et al. Overwintering of Uranotaenia Unguiculata Adult Females in Central Europe: A Possible Way of Persistence of the Putative New Lineage of West Nile Virus?. J Am Mosq Control Assoc 2015; 31: 364-365
• 21 Kolodziejek J, Seidel B, Jungbauer C. et al. West Nile virus positive blood donation and subsequent entomological investigation, Austria, 2014. PLoS One 2015; 10: e0126381
• 22 Koenraadt CJM, Möhlmann TWR, Verhulst NO. et al. Effect of overwintering on survival and vector competence of the West Nile virus vector Culex pipiens. Parasit Vectors 2019; 12: 1-9
• 23 Kampen H, Tews BA, Werner D. First Evidence of West Nile Virus Overwintering in Mosquitoes in Germany. Viruses 2021; 13: 2463
• 24 Kolodziejek J, Marinov M, Kiss BJ. et al. The complete sequence of a West Nile virus lineage 2 strain detected in a Hyalomma marginatum marginatum tick collected from a song thrush (Turdus philomelos) in eastern Romania in 2013 revealed closest genetic relationship to strain Volgograd 2007. PLoS One 2014; 9: e109905
• 25 Bunning ML, Bowen RA, Cropp B. et al. Experimental infection of horses with West Nile virus and their potential to infect mosquitoes and serve as amplifying hosts. Ann N Y Acad Sci 2006; 951: 338-339
• 26 Venter M, Steyl J, Human S. et al. Transmission of West Nile virus during horse autopsy. Emerg Infect Dis 2010; 16: 573-575
• 27 Hinckley AF, OʼLeary DR, Hayes EB. Transmission of West Nile virus through human breast milk seems to be rare. Pediatrics 2007; 119: e666-e671
• 28 Marnezi M, Tsiakalos A, Akinosoglou K. Correlation Between West Nile Virus and Pregnancy: A Systematic Review. Pathogens 2024; 13: 1129
• 29 Venter M, Human S, van Niekerk S. et al. Fatal neurologic disease and abortion in mare infected with lineage 1 West Nile virus, South Africa. Emerg Infect Dis 2011; 17: 1534-1536
• 30 Vlaskamp DRM, Thijsen SFT, Reimerink J. et al. First autochthonous human West Nile virus infections in the Netherlands, July to August 2020. Euro Surveill 2020; 25: 1-4
• 31 Marcantonio M, Rizzoli A, Metz M. et al. Identifying the environmental conditions favouring West Nile Virus outbreaks in Europe. PLoS One 2015; 10: e0121158
• 32 Schwarz ER, Long MT. Comparison of West Nile Virus Disease in Humans and Horses: Exploiting Similarities for Enhancing Syndromic Surveillance. Viruses 2023; 15: 1230
• 33 Sejvar JJ. Clinical Manifestations and Outcomes of West Nile Virus Infection. Viruses 2014; 6: 606-623
• 34 Heus P de Kolodziejek J, Camp JV. et al. Emergence of West Nile Virus Lineage 2 in Europe: Characteristics of the First Seven Cases of West Nile Neuroinvasive Disease in Horses in Austria. Transbound Emerg Dis 2020; 67: 1189-1197
• 35 Ostlund EN, Crom RL, Pedersen DD. et al. Equine West Nile encephalitis, United States. Emerg Infect Dis 2001; 7: 665-669
• 36 Weese JS, Baird JD, DeLay J. et al. West Nile virus encephalomyelitis in horses in Ontario: 28 Cases. Can Vet J 2003; 44: 469-473
• 37 Bunning ML, Bowen RA, Cropp CB. et al. Experimental infection of horses with West Nile virus. Emerg Infect Dis 2002; 8: 380-386
• 38 García-Bocanegra I, Arenas-Montes A, Jaén-Téllez JA. et al. Use of sentinel serosurveillance of mules and donkeys in the monitoring of West Nile virus infection. Vet J 2012; 194: 262-264
• 39 Murgue B, Murri S, Zientara S. et al. West Nile outbreak in horses in southern France, 2000: the return after 35 years. Emerg Infect Dis 2001; 7: 692-696
• 40 Silva ASG, Matos ACD, da Cunha MACR. et al. West Nile Virus associated with equid encephalitis in Brazil, 2018. Transbound Emerg Dis 2019; 66: 445-453
• 41 Porter MB, Long MT, Getman LM. et al. West Nile virus encephalomyelitis in horses: 46 cases (2001). J Am Vet Med Assoc 2003; 222: 1241-1247
• 42 Cavalleri JV, Korbacska-Kutasi O, Leblond A. et al. European College of Equine Internal Medicine consensus statement on equine flaviviridae infections in Europe. J Vet Intern Med 2022; 36: 1858-1871
• 43 Wang H, Siddharthan V, Hall JO. et al. Autonomic Nervous Dysfunction in Hamsters Infected with West Nile Virus. PLoS One 2011; 6: e19575
• 44 Fehér OE, Fehérvári P, Tolnai CH. et al. Epidemiology and Clinical Manifestation of West Nile Virus Infections of Equines in Hungary, 2007–2020. Viruses 2022; 14: 2551
• 45 Beck C, Jimenez-Clavero MA, Leblond A. et al. Flaviviruses in Europe: complex circulation patterns and their consequences for the diagnosis and control of West Nile disease. Int J Environ Res Public Health 2013; 10: 6049-6083
• 46 Davidson AH, Traub-Dargatz JL, Rodeheaver RM. et al. Immunologic responses to West Nile virus in vaccinated and clinically affected horses. J Am Vet Med Assoc 2005; 226: 240-245
• 47 Bielefeldt-Ohmann H, Bosco-Lauth A, Hartwig AE. et al. Characterization of non-lethal West Nile Virus (WNV) infection in horses: subclinical pathology and innate immune response. Microb Pathog 2017; 103: 71-79
• 48 Porter MB, Long M, Gosche DG. et al. mmunoglobulin M-capture enzyme-linked immunosorbent assay testing of cerebrospinal fluid and serum from horses exposed to west nile virus by vaccination or natural infection. J Vet Intern Med 2004; 18:: 866-870
• 49 Monaco F, Purpari G, Di Gennaro A. et al. Immunological Response in Horses Following West Nile Virus Vaccination with Inactivated or Recombinant Vaccine. Vet Ital 2019; 55: 73-79
• 50 Rebollo B, Sarraseca J, Lecollinet S. et al. Monitoring Anti-NS1 Antibodies in West Nile Virus-Infected and Vaccinated Horses. Biomed Res Int 2018; 2018: 8309816
• 51 Diamond MS, Sitati EM, Friend LD. et al. A critical role for induced IgM in the protection against West Nile virus infection. J Exp Med 2003; 198: 1853-1862
• 52 Cantile C, Del Piero F, Di Guardo G. et al. Pathologic and immunohistochemical findings in naturally occurring West Nile virus infection in horses. Vet Pathol 2001; 38: 414-421
• 53 Qian X, Qi Z. Mosquito-Borne Flaviviruses and Current Therapeutic Advances. Viruses 2022; 14: 1226
• 54 American Association of Equine Practitioners. West Nile Virus Vaccination Guidelines (20.4.2024). https://aaep.org/resource/west-nile-virus-vaccination-guidelines/
• 55 Lacombe VA, Furr M. Differential Diagnosis and Management of Horses with Seizures or Alterations in Consciousness. In: Furr M, Reed S. Hrsg. Equine Neurology. 2. Aufl.. Hoboken (NJ): John Wiley & Sons; 2015: 79-92
• 56 Johnson SA. Rehabilitation Strategies for the Neurologic Horse. Vet Clin North Am Equine Pract 2022; 38: 379-396
• 57 Minke JM, Siger L, Cupillard L. et al. Protection provided by a recombinant ALVAC(^®)-WNV vaccine expressing the prM/E genes of a lineage 1 strain of WNV against a virulent challenge with a lineage 2 strain. Vaccine 2011; 29: 4608-4612
• 58 Fehér O, Bakonyi T, Barna M. et al. Serum neutralising antibody titres against a lineage 2 neuroinvasive West Nile Virus strain in response to vaccination with an inactivated lineage 1 vaccine in a European endemic area. Vet Immunol Immunopathol 2020; 227: 110087
• 59 Joó K, Bakonyi T, Szenci O. et al. Comparison of assays for the detection of West Nile virus antibodies in equine serum after natural infection or vaccination. Vet Immunol Immunopathol 2017; 183: 1-6
• 60 Seino KK, Long MT, Gibbs EPJ. et al. Comparative efficacies of three commercially available vaccines against West Nile Virus (WNV) in a short-duration challenge trial involving an equine WNV encephalitis model. Clin Vaccine Immunol 2007; 14: 1465-1471
• 61 Sejvar J, Davis L, Szabados E. et al. Delayed-onset and recurrent limb weakness associated with West Nile virus infection. J Neurovirol 2010; 16: 93-100
• 62 Arbeitskreis Pferde der StIKo Vet (Ständige Impfkommission Veterinärmedizin). Leitlinie zur Impfung von Pferden, 5. Aufl. (06.01.2025). https://www.tieraerzteverband.de/bpt/berufspolitik/leitlinien/dokumente/impfleitlinien/Impfleitlinie_Pferd_2025-01-06.pdf Stand: 26.03.2025
• 63 Tolnai CH, Forgach PE, Paszerbovics B. et al. Comparison of the long-term humoral immune response against West Nile virus in clinically and inapparently infected horses. 17th European College of Equine Internal Medicine (ECEIM) Congress Copenhagen, Denmark 14–16 November 2024. J Vet Int Med 2025; 39: e17292
• 64 Castillo-Oliveras J, Mansfield K, Phipps L. et al. Antibody response in horses following experimental infection with West Nile virus lineage 1 and 2. Transbound Emerg Dis 2011; 58: 206-212
• 65 Bowen RA, Bosco-Lauth A, Syvrud K. et al. Protection of horses from West Nile virus Lineage 2 challenge following immunization with a whole, inactivated WNV lineage 1 vaccine. Vaccine 2014; 32: 5455-5459