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Int J Sports Med 2023; 44(09): 642-649
DOI: 10.1055/a-2063-0134
Physiology & Biochemistry

Constructing a Diagnosis Model and Visualizing the Risk Relationship between Biomarkers and Overuse Injuries in Well-trained Wrestlers

Huang Xizhang
1   School of Elite Sport, Shanghai University of Sport, Shanghai, China
2   Key Laboratory of Winter Sports Training Monitoring and Control, Heilongjiang Research Institute of Sports Science, Harbin, China
,
Binghong Gao
1   School of Elite Sport, Shanghai University of Sport, Shanghai, China
› Author Affiliations Funding Information Shanghai Key Lab of Human Performance - 11DZ2261100; National Key Research and Development Program of China - 2019YFF0301603
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Abstract

This study aimed to investigate the association between biomarkers and overuse injuries in well-trained wrestlers. Seventy-six well-trained wrestlers on a national team completed two blood sample collections, two clinical overuse injuries diagnoses, and a questionnaire survey at a 2-week interval. Multivariate logistic regression analysis and receiver operating characteristic curve were used to screen for related factors and construct the prediction probability model of overuse injuries. Using a restricted cubic spline further clarifies the relationship between biomarker levels and the risk of overuse injuries. Creatine kinase (CK), cortisol, rheumatoid factor, testosterone in men, and C-reactive protein (CRP) levels in the overuse injuries group were significantly different compared to those in the non-overuse injuries group. The diagnostic efficiency of the prediction probability model was more valuable than any single variable (area under the curve=0.96, Specificity=0.91, Sensitivity=0.89, high accuracy). A J-shaped relationship was noted between biomarkers (cortisol, CRP, and CK) and the risk of overuse injuries (cutoff point: 17.95 μg·dL-1, 4.72 mg·L-1, and 344 U·L-1; p for nonlinearity:<0.001, 0.025, and 0.043, respectively). In conclusion, a predictive model based on biomarkers (cortisol, CRP, and CK) predicted the overuse injuries risk of well-trained wrestlers. High levels of these three biomarkers were associated with a higher risk of overuse injuries, and a J-shaped relationship was observed between them.

Key words

blood marker - sports injury - regression model - elite athletes - risk of injury


Publication History

Received: 10 July 2022

Accepted: 22 March 2023

Accepted Manuscript online:
27 March 2023

Article published online:
01 June 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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