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Synlett 2022; 33(09): 815-821
DOI: 10.1055/a-1796-2255
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Assembling Chiral Center of Heterocycles by Palladium-Catalyzed Asymmetric Hydrocarbonylation

Chaoren Shen
a   Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. of China
b   Institute of Eco-Chongming, Shanghai 202162, P. R. of China
,
Kaiwu Dong  ∗
a   Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. of China
b   Institute of Eco-Chongming, Shanghai 202162, P. R. of China
› Author AffiliationsThe authors acknowledge financial support from the Science and Technology Commission of Shanghai Municipality (Grant Number 20ZR1471400), the Shanghai Rising-Star Program (Grant Number 21QA1402800), the National Key Research and Development Program of China (Grant Number 2020YFA0710200), and the Fundamental Research Funds for the Central Universities.
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Abstract

The strategy of embedding coordinative functional group into the starting material is frequently employed to enhance reactivity and enantioselectivity in various asymmetric catalytic reactions other than enantioselective hydrocarbonylation. Recent progress in palladium-catalyzed asymmetric hydrocarbonylation with this strategy for the synthesis of chiral heterocycles was highlighted. The merits of the innate coordinative functional group not only enhance the reactivity and boost the multiple selectivity, but also facilitates the synthesis of chiral heterocycles.

1 Introduction

2 Challenges in Pd-Catalyzed Asymmetric Hydrocarbonylation

3 Pd-Catalyzed Asymmetric Hydrocarbonylation for the Synthesis of Chiral Heterocycles

4 Summary and Outlook

Key words

carbon monoxide - chiral heterocycles - palladium - directing group - asymmetric hydrocarboxylation


Publication History

Received: 21 February 2022

Accepted after revision: 11 March 2022

Accepted Manuscript online:
11 March 2022

Article published online:
20 April 2022

© 2022. Thieme. All rights reserved

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